Modeling the thermo-acoustic effects of thermal-dependent speed of sound and acoustic absorption of biological tissues during focused ultrasound hyperthermia

Lopez-Haro, S. A.; Gutiérrez, M. I.; Vera, A.; Leija, L.

doi:10.1007/s10396-015-0643-3

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…It is known that porcine fat usually consists of 22% of water and 78% of pure fat [22], and thus, we calculated the absorption coefficient of porcine fat to be ~0.02 cm −1 based on the percentage of water and pure porcine fat and their absorption coefficients [22–25]. (b) Thermoacoustic parameters, including the thermal expansion coefficient,

β

, the speed of sound,

v_{s}

and the specific heat,

C_{p}

: Due to the unavailable thermoacoustic parameters of porcine tissue, those of bovine tissue were used instead [18, 22, 26–29]. (c) Illumination fluence,

F

: the fluence was set to a constant of 1 (i.e.,

F

= 1 in Equation (1)).…”

Section: Methodsmentioning

confidence: 99%

Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Seong

Yang

Han

et al. 2022

Journal of Biophotonics

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Nonlinear photoacoustic microscopy (PAM) is a novel approach to enhance contrast and resolution. In this study, a low‐cost infrared (IR) lamp as a simple approach for nonlinear PAM is demonstrated. Numerical simulations are first performed to verify the nonlinear photoacoustic effect under steady heating for two cases: (a) Differentiation of absorbers with different Grüneisen coefficients; (b) enhancement of photoacoustic amplitude. Then, sets of experiments are conducted to experimentally demonstrate our proposed approach: (a) Longitudinal monitoring of photoacoustic A‐line signals from two samples, porcine tissue ex vivo and hemoglobin and indocyanine green (ICG) solutions in tubes in vitro for demonstrating the above‐mentioned two cases; (b) PAM imaging of hemoglobin and ICG solutions in tubes before and after IR lamp heating. Different signal change and amplitude enhancement are observed in different demonstrations, showing the efficacy of the proposed approach. By virtue of cost‐effectiveness and decent performance, our work facilitates nonlinear PAM studies.

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β

, the speed of sound,

v_{s}

and the specific heat,

C_{p}

: Due to the unavailable thermoacoustic parameters of porcine tissue, those of bovine tissue were used instead [18, 22, 26–29]. (c) Illumination fluence,

F

: the fluence was set to a constant of 1 (i.e.,

F

= 1 in Equation (1)).…”

Section: Methodsmentioning

confidence: 99%

Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Seong

Yang

Han

et al. 2022

Journal of Biophotonics

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“…Imbault has reported clinical data and proposed various methods for improving the accuracy of speed of sound evaluation technology [ 45 – 47 ]. As described by López-Haro [ 48 ], this technology is also being used in therapeutic applications. At present, compounding methods have not been implemented in clinical equipment.…”

Section: Speed Of Sound Evaluationmentioning

confidence: 99%

Basic concept and clinical applications of quantitative ultrasound (QUS) technologies

Yamaguchi

2021

J Med Ultrasonics

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In the field of clinical ultrasound, the full digitalization of diagnostic equipment in the 2000s enabled the technological development of quantitative ultrasound (QUS), followed by multiple diagnostic technologies that have been put into practical use in recent years. In QUS, tissue characteristics are quantified and parameters are calculated by analyzing the radiofrequency (RF) echo signals returning to the transducer. However, the physical properties (and pathological level structure) of the biological tissues responsible for the imaging features and QUS parameters have not been sufficiently verified as there are various conditions for observing living tissue with ultrasound and inevitable discrepancies between theoretical and actual measurements. A major issue of QUS in clinical application is that the evaluation results depend on the acquisition conditions of the RF echo signal as the source of the image information, and also vary according to the model of the diagnostic device. In this paper, typical examples of QUS techniques for evaluating attenuation, speed of sound, amplitude envelope characteristics, and backscatter coefficient in living tissues are introduced. Exemplary basic research and clinical applications related to these technologies, and initiatives currently being undertaken to establish the QUS method as a true tissue characterization technology, are also discussed.

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“…Ultrasonic waves have a variety of applications in medicine, such as drug delivery, lithotripsy, hyperthermia and diagnostic imaging [5][6][7][8][9][10].…”

mentioning

confidence: 99%

Multiphysics Analysis of Ultrasonic Shock Wave Lithotripsy and Side Effects on Surrounding Tissues

2021

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Background: Today, the most common method for kidney stone therapy is extracorporeal shock wave lithotripsy. Current research is a numerical simulation of kidney stone fragmentation via ultrasonic shock waves. Most numerical studies in lithotripsy have been carried out using the elasticity or energy method and neglected the dissipation phenomenon. In the current study, it is solved by not only the linear acoustics equation, but also the Westervelt acoustics equation which nonlinearity and dissipation are involved.Objective: This study is to compare two methods for simulation of shock wave lithotripsy, clarifying the effect of shock wave profiles and stones' material, and investigating side effects on surrounding tissues.Material and Methods: Computational study is done using COMSOL Multiphysics, commercial software based on the finite element method. Nonlinear governing equations of acoustics, elasticity and bioheat-transfer are coupled and solved.Results: A decrease in the rise time of shock wave leads to increase the produced acoustic pressure and enlarge focus region. The shock wave damages kidney tissues in both linear and nonlinear simulation but the damage due to high temperature is very negligible compared to the High Intensity Focused Ultrasound (HIFU). Conclusion:Disaffiliation of wave nonlinearity causes a high incompatibility with reality. Stone's material is an important factor, affecting the fragmentation.

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Modeling the thermo-acoustic effects of thermal-dependent speed of sound and acoustic absorption of biological tissues during focused ultrasound hyperthermia

Abstract: The increment of the achieved temperatures at the treatment zone indicated that the effects produced by the thermal dependence of SOS and absorption must be accounted for when planning hyperthermia treatment in order to avoid overheating undesired regions.

Cited by 7 publications

References 33 publications

Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Basic concept and clinical applications of quantitative ultrasound (QUS) technologies

Multiphysics Analysis of Ultrasonic Shock Wave Lithotripsy and Side Effects on Surrounding Tissues

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