The accurate modeling and understanding of complex transient mixed pipe flows is crucial for the optimal design and safe and efficient operation in pipeline systems such as urban drainage systems. Currently, the predominant approach for modeling free-surface-pressurized flows relies on grid-based numerical schemes, with comparatively limited capability for exploring its complex phenomena. This study proposed a novel one-dimensional numerical model that integrates the smoothed particle hydrodynamics (SPH) method with the Preissmann slot method (PSM) to explore transient mixed flows in pipeline systems, with better potential capability for exploring more mixed flow phenomena. Empirical parameters of the proposed SPH-PSM model were optimized for improving the numerical accuracy and stability, and the applicable range for these empirical parameters was recommended. The performances of the proposed model were evaluated by different flow regimes, including one free surface case, one fully pressurized case, and two transient mixed-flow cases. The simulation results of different flow regimes demonstrated a high level of agreement with the reference data, indicating the good capability of the SPH-PSM model in simulating complex flow regimes in pipeline systems. Therefore, the proposed SPH-PSM model can be an alternative way for modeling, exploring, and understanding the complex transient mixed flows in pipeline systems.