Salinity is an important factor in microalgal mass production that has been less studied than other external factors such as temperature and irradiance. The greater attention paid to the effects of these two factors reflects the important influence that both exert on growth and production of microalgae. 1 However, the ability to control the effects of temperature and irradiance on microalgal production is inversely proportional to the size of the culture system. This especially affects outdoor mass production systems, under which conditions the options for regulating the effects of temperature and irradiance are very limited. Therefore, lower-cost outdoor open production systems are highly dependent on how environmental factors change. In this type of system, salinity takes on a key role as an easier factor to handle to optimize production. Production of freshwater microalgae at higher salinity is possible thanks to the availability of several salttolerant species. [2][3][4][5] Microalgal production in environments of variable salinity may be even more feasible if not only estuarine species