2024
DOI: 10.3389/fnins.2024.1416460
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Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis

Jon I. Arellano,
Pasko Rakic

Abstract: Contrary to humans, adult hippocampal neurogenesis in rodents is not controversial. And in the last three decades, multiple studies in rodents have deemed adult neurogenesis essential for most hippocampal functions. The functional relevance of new neurons relies on their distinct physiological properties during their maturation before they become indistinguishable from mature granule cells. Most functional studies have used very young animals with robust neurogenesis. However, this trait declines dramatically … Show more

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