The dynamic responses of parallel hoisting system with time-varying length and rigid guidance under drive deviation are investigated considering tension and torsion characteristics of the ropes. The variable-domain three-node elements of rope are employed and the corresponding differential algebraic equations (DAEs) are derived using Lagrange’s equations of the first kind. The slack situation of the rope is considered, and the dynamic equations which are systems of DAEs are transformed to ordinary differential equations (ODEs). The dynamic responses of tension, torsion, and acceleration are analyzed considering radius’ error of the drums, which indicates that the drive deviation between ropes can cause large influence on the tension difference and even cause one of the ropes to slack. However, the torsion of the corresponding rope is active. And unreasonable discordance between ropes should be controlled for the design and manufacture of drum on super deep parallel hoisting system.