This study investigates the efficiency of a solar-powered seawater desalination plant (DP) using reverse osmosis for an arid coastal region. The solar models are investigated using local meteorological data, including direct, diffused and global irradiance. The meteorological data are obtained using local typical meteorological data set collected from a ground weather station. The PVsyst simulation tool is used to model a grid-connected solar PV system utilizing three photovoltaic (PV) technologies: thin-film, monocrystalline, and polycrystalline. Three scenarios were considered: restricted area, daily water production and design capacity. The optimum configuration for the restricted area scenario at the seawater DP location considered is an on-grid thin-film module (170 W) with a tilt angle of 20° and an inverter unit of 2000 kW. The solution module area is 15,248 m2. The annual electricity production will be approximately 4251.1 MWh/y, which represents only 3.1% of the DP demand. Thin-films produce higher annual electricity than monocrystalline and polycrystalline silicon by 8.3% and 5.9%, respectively, but require 15.9% and 5.7% more space than monocrystalline and polycrystalline silicon, respectively. For Shuwaikh DP, a 30 MIGD DP will require a PV system with a capacity of 120 MWp at 30° tilt angles and 60 inverters. The design environmental impact was assessed using life cycle assessment (LCA). The carbon footprint will decrease from 7.3 x10-5 to 1.8 x10-5 (kg CO2 equivalent), for the 30 MIGD production. The fossil fuel depletion will decrease by approximately 80%. However, the large number of solar panels and the significant total ground area required for the 30 MIGD. The solar array of 1,531,054 m2 will adversely affect the urban land occupation impact category by 84% and will increase metal depletion by 37%.The response surface optimization indicates that the optimal performance in the coastal region for power desalination plants is achieved when using a thin-film at a tilt angle of 20 o.