To address the problems of high cost, complex operation, and low efficiency of existing equipment for aerospace, a simple but efficient multichannel air tightness detection device is designed. A physical system model is constructed for the process of inflation, deflation, and inflation with leakage. The expression between the inflation/deflation rate and the valve area is obtained. Through modeling the intersection and rotation of spatial curves, the relationship between the valve area and the valve core angle is derived, and the optimal valve core angle calculation method is proposed to achieve precise rate control of inflation and deflation. Simulation experiments and numerical analysis demonstrate the superiority of the proposed system scheme, the effectiveness of the control method, as well as the accuracy of the mathematical model. For the tested object of 0.3 L, the target pressure of 400 KPa, and the inflation and deflation rate of 75 Kpa/min, by using four channels with a 10 s interval for sequential operation and adjusting valves every 60 s, the efficiency of inflation and deflation is more than 3.5 times that of a single device with a single circuit. Its performance is not much different from real-time automatic control equipment, but the economy is greatly improved.