2014
DOI: 10.1098/rsfs.2013.0073
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Modelling chromosome dynamics in mitosis: a historical perspective on models of metaphase and anaphase in eukaryotic cells

Abstract: Mitosis is the process by which the genome is segregated to form two identical daughter cells during cell division. The process of cell division is essential to the maintenance of every form of life. However, a detailed quantitative understanding of mitosis has been difficult owing to the complexity of the process. Indeed, it has been long recognized that, because of the complexity of the molecules involved, their dynamics and their properties, the mitotic events that mediate the segregation of the genome into… Show more

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Cited by 25 publications
(26 citation statements)
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References 64 publications
(116 reference statements)
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“…As mentioned above, most spindle models have examined specific aspects of spindle function ( 46 , 47 ) rather than assembly. Here, we compare our work with previous models of Xenopus meiotic spindle ( 53 , 54 , 69 , 72 , 73 ) and human spindle ( 74 ) assembly.…”
Section: Discussionmentioning
confidence: 99%
“…As mentioned above, most spindle models have examined specific aspects of spindle function ( 46 , 47 ) rather than assembly. Here, we compare our work with previous models of Xenopus meiotic spindle ( 53 , 54 , 69 , 72 , 73 ) and human spindle ( 74 ) assembly.…”
Section: Discussionmentioning
confidence: 99%
“…Computational modeling has been used previously to study the mitotic spindle [3,4,67]. Recent work on spindle and MT organization includes studies of spindle elongation and force balance [59,68], the formation and maintenance of antiparallel MT overlaps [69,70], MT bundling and sliding [15], spindle movements and positioning [71,72], spindle length and shape [15,51,52,73,74], MT organization [75], and spindle assembly from a bipolar initial condition [32,76].…”
Section: Methodsmentioning
confidence: 99%
“…Because of the molecular complexity of the machinery that mediates anaphase B spindle elongation, it is appreciated that a full understanding of the molecular mechanism of anaphase B will require theoretical/quantitative modeling [198]. Theoretical models (Figure 7) that incorporate realistic properties of the spindle and its molecular components can yield solutions that illuminate e.g., the factors that govern the mechanical design of the elongating spindle, describe its dynamic evolution, in plots of spindle length versus time, and display spindle dynamics in a visually accessible manner using computer simulations.…”
Section: Theoretical Models Of Anaphase Bmentioning
confidence: 99%