Recent seismological work has revealed new structures in the boundary layer between the Earth's core and mantle that are altering and expanding perspectives of the role this region plays in both core and mantle dynamics. Clear challenges for future research in seismological, experimental, theoretical and computational geophysics have emerged, holding the key to understanding both this dynamic system and geological phenomena observed at the Earth's surface.The Earth acquired its primary layered structure-consisting of a molten metallic alloy core overlain by a thick shell of silicates and oxides-very early in its history, and the region near the coremantle boundary (CMB) surface has undoubtedly played a significant role in both the core and mantle dynamic systems throughout their subsequent 4.5-Gyr evolution. The CMB has a density contrast exceeding that found at the surface of the Earth, has contrasts in viscosity and physical state comparable to those at the ocean floor, and has much hotter ambient temperatures than found near the surface 1,2 . These factors, together with the requirement that significant heat be flowing from the core into the mantle in order to sustain the geodynamo (the core magnetohydrodynamic flow regime that produces the Earth's magnetic field), provide the basis for the conventional view that a significant thermal boundary layer exists at the base of the mantle, with a temperature contrast of 1;000 Ϯ 500 K (refs 2-4). With ambient temperatures averaging around 3,000 K, this hot thermal boundary layer is a likely source of boundary-layer instabilities, and it has been speculated that upwelling thermal plumes ascend from the CMB to produce surface hotspot volcanism such as at Hawaii and Iceland, transporting about 10-15% of the surface heat flux 5-7 . The large CMB density contrast favours a mantle-side accumulation of chemical heterogeneities derived from initial and continuing chemical differentiation of the mantle, possibly including downwelling subducted slabs of former oceanic lithosphere; distinctive chemical signatures of these heterogeneities may eventually be entrained into thermal plumes, resulting in unique hotspot chemistry 8,9 . There may also be a core-side chemical and thermal boundary layer, but the low seismic velocities and molten state of the core make it much harder to analyse any structure in the outermost core 2 .In the past decade, seismic tomography has provided steadily improving images of deep mantle elastic velocity heterogeneity, revealing the presence of significant large-scale (Ͼ2,000 km) patterns of coherent high-and low-velocity regions at all depths 10-12 , with enhanced lateral variations in the lowermost 300 km. Attributing the seismological variations to lateral thermal and chemical heterogeneity in the boundary layer suggests several mechanisms of coupling between the core and mantle, influencing the core flow regime as well as irregularities in rotation of the planet 2,13-15 . An experimental demonstration that chemical reactions may be continuing betwee...