Modelling decision-making under uncertainty: A direct comparison study between human and mouse gambling data

Cabeza, Lidia; Giustiniani, Julie; Chabin, Thibault; Ramadan, Bahrie; Joucla, Coralie; Nicolier, Magali; Pazart, Lionel; Haffen, Emmanuel; Fellmann, D; Gabriel, Damien; Peterschmitt, Yvan

doi:10.1016/j.euroneuro.2019.11.005

Cited by 13 publications

(20 citation statements)

References 58 publications

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“…From the perspective of clinically relevant translatability, the use of the single-session version might be preferable. However, a recent study showed that mice and humans perform very similarly in Iowa Gambling Task if the experimental parameters were harmonized between the species (Cabeza et al, 2020). This strengthens the face validity of nonconventional, multi-session versions of the task like the one used here.…”

Section: Discussionsupporting

confidence: 73%

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

et al. 2020

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While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects of these drugs remains deficient. In particular, there are gaps in knowledge on executive functions and goal-directed behaviors both in humans and in commonly used animal models. The effects of acute doses of psychedelic lysergic acid diethylamide (LSD) on reward-driven decision making were explored using the mouse version of the Iowa Gambling Task. A total of 15 mice were trained to perform in a touch-screen adaptation of the rodent version of the Iowa Gambling Task, after which single acute doses of LSD (0.025, 0.1, 0.2, 0.4 mg/kg), serotonin 2A receptor-selective agonist 25CN-NBOH (1.5 mg/kg), d-amphetamine (2.0 mg/kg), and saline were administered before the trial. 25CN-NBOH and the three lowest doses of LSD showed no statistically significant changes in option selection or in general functioning during the gambling task trials. The highest dose of LSD (0.4 mg/kg) significantly decreased premature responding and increased the omission rate, but had no effect on option selection in comparison with the saline control. Amphetamine significantly decreased the correct responses and premature responding while increasing the omission rate. In conclusion, mice can perform previously learned, reward-driven decision-making tasks while under the acute influence of LSD at a commonly used dose range.

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Section: Discussionsupporting

confidence: 73%

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

et al. 2020

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“…Animal models employ lesioning techniques, direct circuit modulation, or pharmacological interrogations to assess behaviors, making them highly valuable to disentangle the neuronal pathways and neurotransmitter signaling involved in decisionmaking. As such, evaluating the neurobiological basis of decision-making strategies and outcomes in animal models should employ behavioral methods that have face validity in comparison to human studies [30,41,42]. Given the evidence that deficits in dopaminergic and noradrenergic signaling impair advantageous and strategic decision-making, the question arises as to whether these deficits could also be interrogated in PD patients with the IGT.…”

Section: What Neural Areas and Mechanisms Of Pd Are Probed By The Igt?mentioning

confidence: 99%

Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson’s Disease?

Salvatore

Soto

Alphonso

et al. 2021

JPD

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Up to 23% of newly diagnosed, non-demented, Parkinson’s disease (PD) patients experience deficits in executive functioning (EF). In fact, EF deficits may occur up to 39-months prior to the onset of motor decline. Optimal EF requires working memory, attention, cognitive flexibility, and response inhibition underlying appropriate decision-making. The capacity for making strategic decisions requires inhibiting imprudent decisions and are associated with noradrenergic and dopaminergic signaling in prefrontal and orbitofrontal cortex. Catecholaminergic dysfunction and the loss of noradrenergic and dopaminergic cell bodies early in PD progression in the aforementioned cortical areas likely contribute to EF deficits resulting in non-strategic decision-making. Thus, detecting these deficits early in the disease process could help identify a significant portion of individuals with PD pathology (14–60%) before frank motor impairment. A task to evaluate EF in the domain of non-strategic decision-making might be useful to indicate the moderate loss of catecholamines that occurs early in PD pathology prior to motor decline and cognitive impairment. In this review, we focus on the potential utility of the Iowa Gambling Task (IGT) for this purpose, given significant overlap between in loss of dopaminergic and noradrenergic cells bodies in early PD and the deficits in catecholamine function associated with decreased EF. As such, given the loss of catecholamines already well-underway after PD diagnosis, we evaluate the potential utility of the IGT to identify the risk of therapeutic non-compliance and a potential companion approach to detect PD in premotor stages.

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“…Decision-making was measured using the mGT task the protocol of which we have previously described [30] and is extensively detailed in the SOM. Decision-making performance in the mGT was measured as the percentage of advantageous choices over five 20-trial sessions.…”

Section: Mouse Gambling Task (Mgt)mentioning

confidence: 99%

“…The individual sensitivity to reward [47] was measured using the preference for a sucrose solution over water, as previously described [30].…”

Section: Sucrose Preference Test (Spt)mentioning

confidence: 99%

“…In fact, chronic CORT-treated animals exhibit a behavioural spectrum reminiscent to emotional anxio-depressive symptoms as evidenced in several non-conditioned tasks [27][28][29]. Besides, in gambling tasks, healthy rodents efficiently explore and sample from different options prior to establish their choice strategy upon associative and reinforcement learning, showing a high inter-individual variability, probably shared with humans [30][31][32][33][34][35][36]. Here, we hypothesized that chronic CORT exposure leads to suboptimal DM processing under uncertainty in a mouse Gambling Task.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Exposure to Glucocorticoids Induces Suboptimal Decision-Making in Mice

Cabeza

Ramadan

Giustiniani

et al. 2020

Preprint

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Anxio-depressive symptoms as well as severe cognitive dysfunction including aberrant decision-making (DM) are documented in neuropsychiatric patients with hypercortisolaemia. Yet, the influence of the hypothalamo-pituitary-adrenal (HPA) axis on DM processes remains poorly understood. As a tractable mean to approach this human condition, adult male C57BL/6JRj mice were chronically treated with corticosterone (CORT) prior to behavioural, physiological and neurobiological evaluation. The behavioural data indicate that chronic CORT delays the acquisition of contingencies required to orient responding towards optimal DM performance in a mouse Gambling Task (mGT). Specifically, CORT-treated animals show a longer exploration and a delayed onset of the optimal DM performance. Remarkably, the proportion of individuals performing suboptimally in the mGT is increased in the CORT condition. This variability seems to be better accounted for by variations in sensitivity to negative rather than to positive outcome. Besides, CORT-treated animals perform worse than control animals in a spatial working memory (WM) paradigm and in a motor learning task. Finally, Western blotting neurobiological analyses show that chronic CORT downregulates glucocorticoid receptor expression in the medial Prefrontal Cortex (mPFC). Besides, corticotropin-releasing factor signalling in the mPFC of CORT individuals negatively correlates with their DM performance. Collectively, this study describes how chronic exposure to glucocorticoids induces suboptimal DM under uncertainty in a mGT, hampers WM and motor learning processes, thus affecting specific emotional, motor, cognitive and neurobiological endophenotypic dimensions relevant for precision medicine in biological psychiatry.

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Modelling decision-making under uncertainty: A direct comparison study between human and mouse gambling data

Cited by 13 publications

References 58 publications

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson’s Disease?

Chronic Exposure to Glucocorticoids Induces Suboptimal Decision-Making in Mice

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