The investigation of fatigue crack propagation and fracture mechanisms in high-thickness metal plates holds pivotal importance in the advancement of a three-dimensional damage tolerance assessment methodology. This research also bears significant implications for ensuring the safe operation of large-scale mechanical equipment. In this study, we examine the influence of specimen thickness on the evolution of fatigue crack shapes in an aluminum alloy. Fatigue crack growth tests were conducted on single-edge notch tension specimens to explore the impact of specimen thickness on the shape of fatigue crack growth. Additionally, we propose a calculation model for crack growth shape based on an energy model in this paper. Both experimental and analytical findings indicate that specimen thickness does indeed exert an influence on fatigue crack shape. Specifically, as the specimen thickness increases, the crack shape transitions from resembling a “fingernail” to a “saddle” shape.