More companies are facing challenges in extracting and utilizing knowledge in product lifecycle. To solve this problem, a product lifecycle-oriented knowledge service framework is proposed based on the status review. The proposed framework is supported by four key methods and processes, which include mechanism of knowledge service identification, mechanism of product knowledge service transfer, delivery process of product knowledge service, and performance evaluation of product knowledge service. Different with most of the previous fragmental studies, the proposed systematic knowledge service framework is mainly product lifecycle oriented. In addition, an application in gantry crane design shows that the proposed framework can provide effective lifecycle knowledge support for product development, which will help to promote concurrency and simultaneity in product development process.