Modelling Lipid-Coated Microbubbles in Focused Ultrasound Applications at Subresonance Frequencies

Gümmer, Jonas; Schenke, Sören; Denner, Fabian

doi:10.1016/j.ultrasmedbio.2021.06.012

Cited by 18 publications

(6 citation statements)

References 63 publications

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“…To understand the complex cavitation dynamics of encapsulated microbubbles, several numerical investigations with most attempts to modify the classic equation of cavitation dynamics have been performed by considering the effects of shell properties, such as surface tension and dilatational viscosity [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. Among various encapsulating shells, the lipid shell is more flexible, which can make the microbubbles more prone to occurring cavitation under low-amplitude ultrasound irradiation and it is highly attractive for cavitation-assisted therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the lipid-coated microbubbles deserve more attention because of their current prevalence among clinical agents. Considering the complex interfacial rheology of the lipid shell, some numerical models were further proposed to reasonably simulate the typical asymmetric "compression-only" behavior of the lipid-coated microbubbles [24,26,27,29,32,[35][36][37][38][39][40]. Marmottant et al modeled the asymmetric large-amplitude oscillations of lipid-coated microbubbles by taking the buckling and rupture of the lipid shell into account, whereby the effective surface tension of the lipid shell was separated along three different regimes during the bubble expansion and compression [24].…”

Section: Introductionmentioning

confidence: 99%

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Cavitation Dynamics and Inertial Cavitation Threshold of Lipid Coated Microbubbles in Viscoelastic Media with Bubble–Bubble Interactions

et al. 2021

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Encapsulated microbubbles combined with ultrasound have been widely utilized in various biomedical applications; however, the bubble dynamics in viscoelastic medium have not been completely understood. It involves complex interactions of coated microbubbles with ultrasound, nearby microbubbles and surrounding medium. Here, a comprehensive model capable of simulating the complex bubble dynamics was developed via taking the nonlinear viscoelastic behaviors of the shells, the bubble–bubble interactions and the viscoelasticity of the surrounding medium into account simultaneously. For two interacting lipid-coated bubbles with different initial radii in viscoelastic media, it exemplified that the encapsulating shell, the inter-bubble interactions and the medium viscoelasticity would noticeably suppress bubble oscillations. The inter-bubble interactions exerted a much stronger suppressing effect on the small bubble within the parameters examined in this paper, which might result from a larger radiated pressure acting on the small bubble due to the inter-bubble interactions. The lipid shells make the microbubbles exhibit two typical asymmetric dynamic behaviors (i.e., compression or expansion dominated oscillations), which are determined by the initial surface tension of the bubbles. Accordingly, the inertial cavitation threshold decreases as the initial surface tension increases, but increases as the shell elasticity and viscosity increases. Moreover, with the distance between bubbles decreasing and/or the initial radius of the large bubble increasing, the oscillations of the small bubble decrease and the inertial cavitation threshold increases gradually due to the stronger suppression effects caused by the enhanced bubble–bubble interactions. Additionally, increasing the elasticity and/or viscosity of the surrounding medium would also dampen bubble oscillations and result in a significant increase in the inertial cavitation threshold. This study may contribute to both encapsulated microbubble-associated ultrasound diagnostic and emerging therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cavitation Dynamics and Inertial Cavitation Threshold of Lipid Coated Microbubbles in Viscoelastic Media with Bubble–Bubble Interactions

et al. 2021

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“…It is therefore assumed a constant surface tension above a given surface Aext, a zero surface tension below a surface Ab and a linear variation of the surface tension with shell area A in between, which is (perhaps abusively) called the ‘elastic regime’. Later on, smoother parametrization was proposed to allow for analytical resolution of the dynamics [39,40]. Segers et al recently showed that it was possible to directly retrieve a γfalse(Afalse) curve resembling the ad hoc assumptions proposed by Marmottant et al [38], by analysing the radial oscillations of a shelled bubble under different external static pressures, to scan the different equilibrium areas [11].…”

Section: ‘Buckling’ And/or Rupture Of Lipidic Ucasmentioning

confidence: 99%

Buckling of lipidic ultrasound contrast agents under quasi-static load

Chabouh

Elburg

Versluis

et al. 2023

Phil. Trans. R. Soc. A.

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Collapse of lipidic ultrasound contrast agents under high-frequency compressive load has been historically interpreted by the vanishing of surface tension. By contrast, buckling of elastic shells is known to occur when costly compressible stress is released through bending. Through quasi-static compression experiments on lipidic shells, we analyse the buckling events in the framework of classical elastic buckling theory and deduce the mechanical characteristics of these shells. They are then compared with that obtained through acoustic characterization. This article is part of the theme issue ‘Probing and dynamics of shock sensitive shells’.

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“…In addition, models for viscoelastic media, e.g. Oldroyd-B (Jiménez-Fernández & Crespo, 2005), Kelvin-Voigt (Yang & Church, 2005) and Zener (Hua & Johnsen, 2013) models, and for lipid monolayer coatings of the bubble (Gümmer et al, 2021;Marmottant et al, 2005) are available in APECSS. The radial bubble dynamics are solved using a custom implementation of the embedded Runge-Kutta RK5(4) scheme of Dormand & Prince (1980).…”

Section: Featuresmentioning

confidence: 99%

APECSS: A software library for cavitation bubble dynamics and acoustic emissions

Denner¹,

Schenke²

2023

JOSS

Self Cite

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The dynamics of cavitation bubbles and the acoustic emissions they produce are important in a broad range of engineering applications and natural phenomena, either because the strong energy focusing of the bubble collapse is to be avoided, as it may cause damage to surfaces, or to be exploited, such as in emerging medical applications. APECSS (Acoustic Pulse Emitted by Cavitation in Spherical Symmetry) is a software library to simulate the dynamic behavior and acoustic emissions of cavitation bubbles using an efficient state-of-the-art numerical framework. APECSS supports different Rayleigh-Plesset models for bubble dynamics in incompressible and compressible media with Newtonian or viscoelastic rheology, considering clean or coated bubbles. Acoustic emissions may be modeled under different modeling assumptions using a tailored Lagrangian wave tracking method, including the formation and attenuation of shock waves. APECSS can be extended easily to include custom functionality and may be incorporated into other software frameworks.

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Modelling Lipid-Coated Microbubbles in Focused Ultrasound Applications at Subresonance Frequencies

Cited by 18 publications

References 63 publications

Cavitation Dynamics and Inertial Cavitation Threshold of Lipid Coated Microbubbles in Viscoelastic Media with Bubble–Bubble Interactions

Cavitation Dynamics and Inertial Cavitation Threshold of Lipid Coated Microbubbles in Viscoelastic Media with Bubble–Bubble Interactions

Buckling of lipidic ultrasound contrast agents under quasi-static load

APECSS: A software library for cavitation bubble dynamics and acoustic emissions

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