Modelling Lipid Metabolism to Improve Healthy Ageing

Auley, Mark Mc; Jones, Janette J L; Wilkinson, Darren J.; Kirkwood, Thomas B. L.

doi:10.1186/1471-2105-6-s3-p21

Cited by 12 publications

(8 citation statements)

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“…Maintaining cholesterol metabolism is a subtle balancing act between the amount of cholesterol ingested, absorbed, excreted and synthesised (Mc Auley et al, 2005). Ingested cholesterol, exists as esters, and free cholesterol (Iqbal and Hussain, 2009).…”

Section: Overview Of Cholesterol Metabolismmentioning

confidence: 99%

Mathematically modelling the dynamics of cholesterol metabolism and ageing

et al. 2016

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Section: Overview Of Cholesterol Metabolismmentioning

confidence: 99%

Mathematically modelling the dynamics of cholesterol metabolism and ageing

et al. 2016

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“…An example of this decline is the dysregulation of cholesterol metabolism which is inextricably linked to CVD. Therefore, a keen area of focus is how intrinsic aging impacts whole‐body cholesterol metabolism . Recently, we developed a whole‐body model that attempted to capture whole‐body cholesterol metabolism .…”

Section: Approaches To Modeling Agingmentioning

confidence: 99%

Aging and computational systems biology

Mooney

Morgan

Auley

2016

WIREs Mechanisms of Disease

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Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach endeavors to understand biological systems in a holistic manner, by taking account of intrinsic interactions, while also attempting to account for the impact of external inputs, such as diet. A key technique employed in systems biology is computational modeling, which involves mathematically describing and simulating the dynamics of biological systems. Although a large number of computational models have been developed in recent years, these models have focused on various discrete components of the aging process, and to date no model has succeeded in completely representing the full scope of aging. Combining existing models or developing new models may help to address this need and in so doing could help achieve an improved understanding of the intrinsic mechanisms which underpin aging.

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“…Regardless of the approach that is adopted, a better understanding of aging is especially important due to an increase in age-related pathologies, such as cardiovascular disease (CVD) [ 18 ]. The aim of the systems biology paradigm is to provide an integrated interpretation and understanding of fundamental biological processes from the molecular through to the physiological [ 19 , 20 , 21 , 22 , 23 ]. Central to the systems biology approach is computational modelling, which involves using mathematics to quantitatively represent the dynamics of biological systems.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modelling of Metabolic Regulation in Aging

et al. 2015

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The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk between these two important pathways; however, the mechanisms underpinning their interaction(s) remains poorly understood. In this review, we propose using computational modelling in tandem with experimentation to delineate the mechanism(s). We briefly discuss the main modelling frameworks that could be used to disentangle this relationship and present a reduced reaction pathway that could be modelled. We conclude by outlining the limitations of computational modelling and by discussing opportunities for future progress in this area.

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Modelling Lipid Metabolism to Improve Healthy Ageing

Cited by 12 publications

References 1 publication

Mathematically modelling the dynamics of cholesterol metabolism and ageing

Mathematically modelling the dynamics of cholesterol metabolism and ageing

Aging and computational systems biology

Mathematical Modelling of Metabolic Regulation in Aging

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