In this study, two empirical correlations of the Nusselt number, based on two artificial neural networks (ANN), were developed to determine the heat transfer coefficients for each section of a vertical helical double-pipe evaporator with water as the working fluid. Each ANN was obtained using an experimental database of 1109 values obtained from an evaporator coupled to an absorption heat transformer with energy recycling. The Nusselt number in the annular section was estimated based on the modified Wilson plot method solved by an ANN. This model included the Reynolds and Prandtl numbers as input variables and three neurons in their hidden layer. The Nusselt number in the inner section was estimated based on the Rohsenow equation, solved by an ANN. This ANN model included the numbers of the Prandtl and Jackob liquids as input variables and one neuron in their hidden layer. The coefficients of determination were R 2 > 0.99 for both models. Both ANN models satisfied the dimensionless condition of the Nusselt number. The Levenberg-Marquardt algorithm was chosen to determine the optimum values of the weights and biases. The transfer functions used for the learning process were the hyperbolic tangent sigmoid in the hidden layer and the linear function in the output layer. The Nusselt numbers, determined by the ANNs, proved adequate to predict the values of the heat transfer coefficients of a vertical helical double-pipe evaporator that considered biphasic flow with an accuracy of ±0.2 for the annular Nusselt and ±4 for the inner Nusselt.Generally, in the case of heat exchangers with helical pipelines, it is known that the flow behavior has a greater complexity compared to exchangers that include straight pipes [2]. Due to the generation of vortices, induced by the interaction between the viscous forces and the centrifugal force, a disturbance in the flow is generated, which increases the rate of the heat transfer and the friction losses-a behavior referred to as secondary flow [3].If a helical exchanger transports a biphasic flow, specifically gas-liquid, the complexity is even higher due to the sudden changes in the flow pattern. These phenomena are mainly caused by the sliding between the phases, the orientation of the pipe, and the void fraction, among other additional variables and the relationships between them [4]. Therefore, to know and understand these phenomena, it is necessary to estimate the values of the heat transfer coefficient in the helical exchangers that contain biphasic flows, and hence any method that leads to their calculation is considered useful.One of the methods commonly used to estimate heat transfer coefficients is the Wilson plot method, proposed by Wilson in 1915 and subsequently modified in 1957 [5]. This traditional method quantifies the heat flow for each section by the exchanger through the measurement of the global temperature between the two fluids involved and their rate of heat transfer [6]. One of the most significant advantages of this technique is that it avoids the complex dire...