Ethanol direct injection plus gasoline port injection (EDI+GPI) is a new technology to utilise ethanol fuel more effectively and efficiently in spark-ignition engines by taking the advantages of ethanol fuel and direct injection, such as the cooling effect and anti-knock ability. A full cycle numerical modelling including both port and direct injection sprays was performed to understand the mechanisms behind the experimental results of the EDI+GPI engine. The turbulence-chemistry interaction of the two-fraction-mixture partially premixed combustion was solved by a five-dimensional presumed Probability Density Function table.Effects of direct injection timing on fuel evaporation, mixing, wall-wetting, combustion and emission processes were investigated. The results showed that when the direct injection timing was retarded, the mixture around the spark plug became leaner and the distribution of equivalence ratio became more uneven.Moreover, late direct injection resulted in severe fuel impingement and caused local over-cooling effect and over-rich mixture. Consequently, the combustion speed and temperature were decreased by retarded direct injection timing, leading to reduced NO emission and increased HC and CO emissions. Finally, numerical modelling was performed to investigate the strategy of injecting small amount of ethanol fuel on reducing the fuel impingement and incomplete combustion caused by late direct injection.