In this article we discuss the high vacuum implications on the role of positive load ratios (R = Pmin/Pmax) on the threshold ΔKth and fatigue crack growth (FCG) behavior in commercial alloys. It is experimentally observed that the ΔKth is independent of R in vacuum. Also, for a given applied ΔK, FCG rate is weakly dependent of R over the entire range of crack growth rates for several alloys. In addition, limited data on both short and long crack FCG in vacuum results fall within the same experimental scatter suggesting that a typical small crack FCG effect observed in lab air was insignificant or diminished in vacuum. A marginal R‐ratio effects on ΔKth in vacuum are seen for materials with different microstructures, yield strengths, elastic modulus, work hardening properties, and slip modes. The provided analysis and examples seem to imply that FCG in vacuum be primarily dependent on applied ΔK that comes from mechanical driving force. Possible mechanistic explanations are given.