Modelling of Economic Losses due to Some Important Diseases in Goats in India

Singh, B.; Prasad, Shiv

doi:10.22004/ag.econ.47686

Cited by 7 publications

References 4 publications

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Immunogenicity assessment of Clostridium perfringens type D epsilon toxin epitope-based chimeric construct in mice and rabbit

et al. 2020

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Epsilon toxin (Etx) belongs to family of pore-forming toxin and is produced by Clostridium perfringens type D. The Etx toxin is responsible for the pathogenesis of enterotoxaemia in sheep and goats, and occasionally in other livestock animals. The present study aimed to develop a Clostridium perfringens epsilon toxin-based chimeric epitope construct having immunodominant B-cell epitope and universal T-cell epitope and its immunogenicity was evaluated in mice and rabbit. An artificial chimeric epitope construct (CEC) was prepared by joining tandem repeats of a peptide containing amino acids (aa) 134-145 of epsilon toxin B-cell epitope and universal T-cell epitopes. The CEC was expressed in the Escherichia coli following codon optimization for efficient translational efficiency and purified by affinity chromatography. The antigenic reactivity of r-CEC proteins was confirmed by western blot with rabbit anti-r-Etox hyperimmune sera. The immunogenicity of the recombinant single CEC was examined in mice and rabbit by indirect ELISA. It was found that r-CEC yielded high titers of neutralizing antibodies (≥ 1.035 IU/ml) in immunized mice and rabbit. The potency of chimeric protein immunized serum was observed to be higher than the recommended level (0.1-0.3 IU/ml) for protection in sheep and goats. This indicated the potential ability of the chimeric protein as a vaccine candidate. This further requires studying the immune response in targeted host species (sheep and goat).

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Immunogenicity assessment of Clostridium perfringens type D epsilon toxin epitope-based chimeric construct in mice and rabbit

et al. 2020

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Common Infectious Diseases of Goats in Chittagong District of Bangladesh

Nath¹,

Bhuiyan²,

Mamun³

et al. 2014

IJSRAS

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The economic impact of peste des petits ruminants in India

2017

Rev. Sci. Tech. OIE

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Peste des petits ruminants (PPR) is an economically important livestock disease which affects a vast section of the small ruminant population in India. However, data on the incidence of PPR are limited and scant literature is available on the economic losses caused by the disease. In the present study, a structured sampling design was adopted, which covered the major agro-climatic regions of the country, to ascertain the morbidity and mortality rates of PPR. Available estimates of the economic losses in India due to various livestock diseases are based on single values of various epidemiological and economic parameters. Stochastic modelling was used to estimate the economic impact of PPR. Overall annual morbidity and mortality rates of PPR for small ruminants in India have been estimated from the sample as being 8%and 3.45%, respectively. The authors have analysed variations in these rates across species, age group, sex, season and region. The expected annual economic loss due to PPR in India ranges from as little as US $2 million to $18 million and may go up to US $1.5 billion; the most likely range of expected economic losses is between US $653 million and $669 million. This study thus reveals significant losses due to the incidence of PPR in small ruminants in India.

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Modelling of Economic Losses due to Some Important Diseases in Goats in India

Cited by 7 publications

References 4 publications

Immunogenicity assessment of Clostridium perfringens type D epsilon toxin epitope-based chimeric construct in mice and rabbit

Immunogenicity assessment of Clostridium perfringens type D epsilon toxin epitope-based chimeric construct in mice and rabbit

Common Infectious Diseases of Goats in Chittagong District of Bangladesh

The economic impact of peste des petits ruminants in India

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