Modelling of magnetic bead transport in a microvascular network

Vicentini, Marta; Ferrero, Riccardo; Manzin, A.

doi:10.1016/j.jmmm.2020.167234

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…Inter‐endothelial routes comprise pores or open fenestrations in the tumor blood vessels, while trans‐endothelial pathways are based on transcytosis by tumor endothelial cells. [ 49–51 ] As corroborated by micro‐CT imaging, high‐resolution optical imaging and numerical modeling, the spatial‐temporal distribution of nanomaterials in the target tissue is not uniform, with the formation of high‐density agglomerates imposed by the host biological matrices, [ 52–56 ] as simplified in the schematic of Figure a. This effect can be amplified in the presence of magnets with collecting action [ 57 ] and, in the case of magnetic hyperthermia, it can lead to a heat deposition variable in space and in time and, consequently, to a heterogeneous temperature increase.…”

Section: Resultsmentioning

confidence: 99%

From Micromagnetic to In Silico Modeling of Magnetic Nanodisks for Hyperthermia Applications

Manzin

Ferrero

Vicentini

2021

Advcd Theory and Sims

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Magnetic nanodisks have been recently proposed as biomedical tools for therapeutics at the nanoscale level, with a special focus on hyperthermia for cancer cure. Here we present a detailed study of permalloy nanodisks to be used in alternative to superparamagnetic iron oxide nanoparticles, as efficient heating agents that release heat via magnetic hysteresis. A micromagnetic modeling analysis is carried out to identify sizes and ac field parameters that maximize the specific loss power (SLP), guaranteeing the fulfillment of biophysical constraints (Hergt–Dutz limit) and vortex state at remanence (reduced agglomeration effects). The highest SLP (790 W g−1) is found for 100 nm diameter and 20 nm thickness nanodisks, excited at a frequency of 75 kHz. Further analysis elucidates the influence of magnetostatic interactions and local nanodisk‐field orientation on the SLP of nanodisk clusters, which originate from the deposition in target tissues. At high concentrations, magnetostatic interactions can lead to a reduction of 40–50% in the hysteresis losses. From thermal simulations, we finally demonstrate that in a murine model temperature increments comparable to that obtained in calorimetric measurements under quasi‐adiabatic conditions can be achieved only by using an order of magnitude larger dosage of nanodisks, due to blood perfusion effects.

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Section: Resultsmentioning

confidence: 99%

From Micromagnetic to In Silico Modeling of Magnetic Nanodisks for Hyperthermia Applications

Manzin

Ferrero

Vicentini

2021

Advcd Theory and Sims

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“…the time evolution of the vector position s and velocity v ) of a generic MOLND with mass χ , hydrodynamic radius R hyd and magnetic moment m by the following equation:where μ f , η f and v f are the magnetic permeability, viscosity and velocity of the fluid within the micro-channel, here considered to be water. 39 Neglecting the contribution of the chitosan or dextran coating, the MOLND mass χ was determined as: χ = ρ core V core + ρ MNPs V MNPs where ρ core and ρ MNPs are the densities of the MOLND core and of the decorating MNPs. The volumes of the core and of the MNP aggregates were extracted from DLS measurements and observation of SEM/TEM images, assuming as a first approximation that the MNP aggregates form a uniform layer on top of the OLND surface.…”

Section: Methodsmentioning

confidence: 99%

“…where μ f , η f and v f are the magnetic permeability, viscosity and velocity of the fluid within the micro-channel, here considered to be water. 39 Neglecting the contribution of the chitosan or dextran coating, the MOLND mass χ was determined as:…”

Section: Numerical Modeling Of Magnetic Nanodroplet Flow Under Magnet...mentioning

confidence: 99%

Dual-responsive magnetic nanodroplets for controlled oxygen release via ultrasound and magnetic stimulation

Galati,

Vassallo,

Vicentini

et al. 2024

Nanoscale

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“…where N beads is the number of beads, m bead,n is the magnetic moment of the n-th bead, and r n is the vector position of its barycenter [41]. The bead magnetic moment was approximated by means of the Langevin function:…”

Section: Calculation Of Bead Stray Field and Magnetic Forcementioning

confidence: 99%

“…where µ fluid is the magnetic permeability of the fluid in which the beads are immersed, here assumed to be equal to the vacuum permeability µ 0 [41,42].…”

Section: Calculation Of Bead Stray Field and Magnetic Forcementioning

confidence: 99%

Application of Magnonic Crystals in Magnetic Bead Detection

2022

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This paper aims at studying a sensor concept for possible integration in magnetic field-based lab-on-chip devices that exploit ferromagnetic resonance (FMR) phenomena in magnonic crystals. The focus is on 2D magnetic antidot arrays, i.e., magnetic thin films with periodic non-magnetic inclusions (holes), recently proposed as magnetic field sensor elements operating in the gigahertz (GHz) range. The sensing mechanism is here demonstrated for magnetic nano/microbeads adsorbed on the surface of permalloy (Ni80Fe20) antidot arrays with a rhomboid lattice structure and variable hole size. Through extensive micromagnetic modelling analysis, it is shown that the antidot arrays can be used as both bead traps and high-sensitivity detectors, with performance that can be tuned as a function of bead size and magnetic moment. A key parameter for the detection mechanism is the antidot array hole size, which affects the FMR frequency shifts associated with the interaction between the magnetization configuration in the nanostructured film and the bead stray field. Possible applications of the proposed device concept include magnetic immunoassays, using magnetic nano/microbeads as probes for biomarker detection, and biomaterial manipulation.

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Modelling of magnetic bead transport in a microvascular network

Cited by 4 publications

References 24 publications

From Micromagnetic to In Silico Modeling of Magnetic Nanodisks for Hyperthermia Applications

From Micromagnetic to In Silico Modeling of Magnetic Nanodisks for Hyperthermia Applications

Dual-responsive magnetic nanodroplets for controlled oxygen release via ultrasound and magnetic stimulation

Application of Magnonic Crystals in Magnetic Bead Detection

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