With the vigorous development of industry and information technology, people's requirements for sensors are becoming more and more diversified and universal. It is still a challenge to find a new type of pressure sensor with low cost, simple preparation, wider pressure test range, and higher sensitivity. Hereby, we report a novel flexible pressure sensor with a wide pressure detection range and robust mechanical properties, taking advantage of transition metal sulfide NiS2, adsorbed in melamine sponge as the active substance. The flexible sensor deforms under pressure with a internal microstructure change and a corresponding conductivity ramping. The addition of elastic polyvinylidene fluoride after curing improves the impact resistance and enables higher stability. Experiments show that the resistance pressure sensor responds within a wide range of 50 kPa with a high sensitivity of below 0.0345 kPa−1 and a fast response time of 0.64 s. Its excellent performance makes the sensor promising for wearable electronics and health monitoring devices.