<span>From the middle of XX century, natural gas is an important mineral, widely used in the energy sector. Transportation of natural gas is carried out via gas pipeline networks and compression stations. One of the key features which need to be implemented for any centrifugal gas compressor is a surge protection. This article describes the method and develops software application intended for simulation and study of surge protection system of a centrifugal compressor used in modern gas compression stations. Within the article research method, modelling environment’s block diagram, proposed algorithms and results are described. For surge cases control and prediction, Anti-surge control block implemented which based on practical experience and centrifugal compressor theory. To avoid complicated energy balancing differential equations the volumetric flow calculation algorithm proposed which is used in combination with Redlich-Kwong equation of state. Developed software’s adequacy test performed through modeling of one-stage gas compression scheme at rated speed with comparison of parameters with reference commercial software and verification of the anti-surge control system.</span>