Modelling prediction of the microcapsule size of polyelectrolyte complexes produced by atomization

Herrero, Edgar P.; Valle, Eva M. Martín del; Galán, Miguel Á.

doi:10.1016/j.cej.2006.04.003

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…They have studied the effect of the alginate solution viscosity and flow rate and air flow rate. They have also developed a mathematical semi-empirical model, based on the wave mechanism, to predict the size of the microcapsules produced by atomization [13]. Therefore, the main aim of this work is to develop a temporal stability analysis to model the atomization of a swirling viscous annular liquid sheet emanating from an air-blast atomizer subject to inner and outer inviscid swirling air streams.…”

Section: Introductionmentioning

confidence: 99%

Instability study of a swirling annular liquid sheet of polymer produced by air-blast atomization

Herrero¹,

Valle²,

Galán³

2007

Chemical Engineering Journal

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Section: Introductionmentioning

confidence: 99%

Instability study of a swirling annular liquid sheet of polymer produced by air-blast atomization

Herrero¹,

Valle²,

Galán³

2007

Chemical Engineering Journal

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“…As a consequence, a hydrogel is formed due to the bonding between the divalent cations and the carboxyl groups of the guluronic acid. This gelation mechanism follows the egg-box model, which has been extensively studied in literature [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…As an example, an air-blast atomization was used to create a flow of highly viscous solutions of alginate on barium chloride, controlling the different jet breakup modes (from Rayleigh breakup to atomization), obtaining particles around 30 microns [13]. The process was theoretically studied in terms of the most important dimensionless numbers (Weber and Ohnesorge) regarding jet breakup, to verify the effect of the viscosity and surface tension forces [8]. Films of alginate with barium chloride were also produced and used in tissue regeneration without showing toxicity towards healthy cells [14].…”

Section: Introductionmentioning

confidence: 99%

Tuning Alginate Microparticle Size via Atomization of Non-Newtonian Fluids

et al. 2021

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A new approach based on the atomization of non-Newtonian fluids has been proposed to produce microparticles for a potential inhalation route. In particular, different solutions of alginate were atomized on baths of different crosslinkers, piperazine and barium chloride, obtaining microparticles around 5 and 40 microns, respectively. These results were explained as a consequence of the different viscoelastic properties, since oscillatory analysis indicated that the formed hydrogel beads with barium chloride had a higher storage modulus (1000 Pa) than the piperazine ones (20 Pa). Pressure ratio (polymer solution-air) was identified as a key factor, and it should be from 0.85 to 1.00 to ensure a successful atomization, obtaining the smallest particle size at intermediate pressures. Finally, a numerical study based on dimensionless numbers was performed to predict particle size depending on the conditions. These results highlight that it is possible to control the microparticles size by modifying either the viscoelasticity of the hydrogel or the experimental conditions of atomization. Some experimental conditions (using piperazine) reduce the particle size up to 5 microns and therefore allow their use by aerosol inhalation.

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“…Gupta et al (2004) studied experimentally the effect of microcapsule wall constitution, wall thickness, drug loading time, and drug molecular weight on the release properties of microcapsules. Herrero et al (2006) proposed two semi-empirical models to predict the microcapsule size obtained from air-blast atomization of alginate solution. Goubergrits et al (2002) used a computational fluid dynamics (CFD) method to investigate the mass transport phenomena inside a microcapsule.…”

Section: Introductionmentioning

confidence: 99%

A Mathematical Model Characterizing the Diffusion Properties of Microcapsules

Nassar

Păun

et al. 2010

Chemical Engineering Communications

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In this article, we present a mathematical model to describe the diffusion of dextran through spherical microcapsules. Dextran was first allowed to diffuse into the microcapsules for a certain length of time (loading period). After the loading process was complete, the microcapsules were immersed in water medium, and the released concentration of dextran in the medium was measured over time. To demonstrate the applicability of the diffusion model, it was fit to the dextran release data (Gupta et al., 2004), and estimates of the diffusion coefficients in the core and wall of a microcapsule were obtained. From such estimates, one may be able to characterize the diffusion (or release) properties of microcapsules with different wall or membrane thicknesses, wall constitutions, loading times, and dextran molecular weights. Results from such a model can help in the planning and design of experiments.

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Modelling prediction of the microcapsule size of polyelectrolyte complexes produced by atomization

Cited by 16 publications

References 27 publications

Instability study of a swirling annular liquid sheet of polymer produced by air-blast atomization

Instability study of a swirling annular liquid sheet of polymer produced by air-blast atomization

Tuning Alginate Microparticle Size via Atomization of Non-Newtonian Fluids

A Mathematical Model Characterizing the Diffusion Properties of Microcapsules

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