Population mobility, increasing demand for transportation, and the complexity of land use have an impact on environmental quality degradation and air quality pollution. This study aims to analyze (1) the effect of population mobility, increased traffic volume, and land use change on air quality pollution, (2) direct and indirect effects of urban activities, transportation systems, and movement patterns on environmental quality degradation and air pollution index, and (3) air pollution strategy and sustainable urban environmental management. The research method used is a sequential explanation design. Data were obtained through observation, surveys, in-depth interviews, and documentation. The results of the study illustrate that the business center and Daya terminal with a value of 0.18 µgram/m3 is polluted, the power plant and Sermani industrial area with a value of 0.16 µgram/m3 is polluted, the Makassar industrial area with a value of 0.23 is heavily polluted, and the Hasanuddin International Airport area with a value of 0.04 µgram/m3 is not polluted. Population mobility, traffic volume, and land use changes have a significant effect on environmental quality degradation, with a determination coefficient of 94.1%. The direct effect of decreasing environmental quality on the air pollution index is 66.09%. This study recommends transportation management on the main road corridor of Makassar City, which is environmentally friendly with regard to sustainable environmental management.