Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues

Dubois‐Deruy, Emilie; Rémy, Gaëlle; Alard, Jeanne; Kervoaze, Gwenola; Chwastyniak, Maggy; Baron, Morgane; Beury, Delphine; Siegwald, Léa; Caboche, Ségolène; Hot, David; Gosset, Philippe; Grangette, Corinne; Pinet, Florence; Wolowczuk, Isabelle; Pichavant, Muriel

doi:10.3390/nu12030827

Cited by 10 publications

(6 citation statements)

References 69 publications

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“…An analysis of other compounds that appear in cigarettes (i.e, carbon oxide, PAHs) also demonstrated their influence on increased lipolysis and adipokine secretion disorders. Such changes increase the risk of occurrence of cardiovascular diseases as well as metabolic diseases and their risk factors [ 80 , 81 , 82 ].…”

Section: Abdominal Obesitymentioning

confidence: 99%

Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review

Górna

Napierała

Florek

2020

Toxics

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The metabolic syndrome is a combination of several metabolic disorders, such as cardiovascular disease, atherosclerosis, and type 2 diabetes. Lifestyle modifications, including quitting smoking, are recommended to reduce the risk of metabolic syndrome and its associated complications. Not much research has been conducted in the field of e-cigarettes and the risk of metabolic syndrome. Furthermore, taking into account the influence of e-cigarettes vaping on the individual components of metabolic syndrome, i.e, abdominal obesity, insulin resistance, dyslipidemia and elevated arterial blood pressure, the results are also ambiguous. This article is a review and summary of existing reports on the impact of e-cigarettes on the development of metabolic syndrome as well as its individual components. A critical review for English language articles published until 30 June 2020 was made, using a PubMed (including MEDLINE), Cochrane, CINAHL Plus, and Web of Science data. The current research indicated that e-cigarettes use does not affect the development of insulin resistance, but could influence the level of glucose and pre-diabetic state development. The lipid of profile an increase in the TG level was reported, while the influence on the level of concentration of total cholesterol, LDL fraction, and HDL fraction differed. In most cases, e-cigarettes use increased the risk of developing abdominal obesity or higher arterial blood pressure. Further research is required to provide more evidence on this topic.

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Section: Abdominal Obesitymentioning

confidence: 99%

Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review

Górna

Napierała

Florek

2020

Toxics

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“…In the present study, our results indicated that active smoking directly affectd the digestive tract microbiota which then resulted to the alteration of some biochemical components. Chronic cigarette smoke exposure has been reported to modulate cecal microbiota, increase inflammation of the small intestine, and decrease blood leptin level in mice ( Dubois-Deruy et al., 2020 ). A recent study indicated smoking induced gut microbiota dysbiosis, broke metabolism homeostasis and caused insulin resistance in mice ( Yang et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats

Wang

et al. 2021

Front. Cell. Infect. Microbiol.

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Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reductions in serum insulin and leptin levels. Active smoking induced region-specific shifts in microbiota structure, composition, network correlation and metabolism function along the digestive tract. Our results demonstrated that active smoking resulted in a reduced abundance of some potentially beneficial genera (i.e. Clostridium, Turicibacter) and increased abundance of potentially harmful genera (i.e. Desulfovibrio, Bilophila). Functional prediction suggested that amino acid, lipid, propanoate metabolism function could be impaired and antioxidant activity may be triggered. Active smoking may be an overlooked risk to health through its potential effects on the digestive tract microbiota, which is involved in the cause and severity of an array of chronic diseases.

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“…Meanwhile, the in vitro trials proved that cardiac function is impaired by high load [309] . In another study focusing on the toxic effects of cigarette smoke on obese mice, Dubois-Deruy et al reported that chronic cigarette smoke exposure increased the area of cardiomyocytes in C57BL/6JRj mice on a low-fat diet, but not in mice on a high-fat diet [310] . Epidemiologic studies have also reported cigarette smoke-induced cardiac hypertrophy.…”

Section: Cardiovascular-related Key Events Triggered By Cigarette And...mentioning

confidence: 99%