Modelling the impact of repeat asymptomatic testing policies for staff on SARS-CoV-2 transmission potential

Whitfield, Carl A.; Hall, Ian

doi:10.1016/j.jtbi.2022.111335

Cited by 6 publications

(11 citation statements)

References 61 publications

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“…Finally, the third study [28] demonstrated that the strategy to regularly test asymptomatic workers is a highly effective measure to reduce transmission of SARS-CoV-2 in workplaces.…”

Section: Analyses Of Scenariomentioning

confidence: 96%

“…Then, we evaluated the eligibility of the include papers by full text. The final screening resulted in the inclusion of three papers [26][27][28], as discussed below.…”

Section: Analyses Of Scenariomentioning

confidence: 99%

“…Then, we evaluated the eligibility of the include papers by full text. The final screening resulted in the inclusion of three papers [26][27][28], as discussed below. The paper published by Maldin-Morgenthau and colleagues [26] describes the results of a roundtable discussion held in 2006 in New York City, attended by 20 major USA corporate and business stakeholders from different industry sectors: information technology, finance, pharmaceuticals, transportation, aerospace, consumer products, utilities, communications, energy and defense.…”

Section: Analyses Of Scenariomentioning

confidence: 99%

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Pandemic Preparedness among Big Energy Companies: Call to Research and Action

Gualano

Villani

Ricciardi

2023

IJERPH

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The COVID-19 pandemic, as a global phenomenon, has affected all the working realities, worldwide, with the same issues. The aim of the present work is to assess the experiences of management and their preparedness during the pandemic among big companies, in particular, in the energy sector. Based on an overview of scientific evidence and grey literature, we found that big companies followed evidence-based decision-making practices and offered preparedness and information plans. Specifically, these plans contained recommendations and best practices to be followed to avoid the risk of infection in the workplaces, as well as in the field of epidemiological surveillance and vaccination. Nevertheless, many research efforts are required, and it is important that a large number of big companies and corporations address these challenges worldwide, adopting a new sustainable approach that includes both the productivity and health of the workers. A Call to Action was then issued in order to achieve evidence-based leadership to address current and future public health emergency scenarios.

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“…Finally, the third study [28] demonstrated that the strategy to regularly test asymptomatic workers is a highly effective measure to reduce transmission of SARS-CoV-2 in workplaces.…”

Section: Analyses Of Scenariomentioning

confidence: 96%

“…Then, we evaluated the eligibility of the include papers by full text. The final screening resulted in the inclusion of three papers [26][27][28], as discussed below.…”

Section: Analyses Of Scenariomentioning

confidence: 99%

Section: Analyses Of Scenariomentioning

confidence: 99%

See 1 more Smart Citation

Pandemic Preparedness among Big Energy Companies: Call to Research and Action

Gualano

Villani

Ricciardi

2023

IJERPH

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“…23.23287633 doi: medRxiv preprint In multi-scale epidemic modelling frameworks, within-host viral dynamics models, which describe how the viral load of an infected host evolves over the course of infection and can be calibrated to longitudinal individual data, are used to inform population-level epidemiological models (23)(24)(25). One advantage of such approaches is that they facilitate a detailed description of the impact of interventions, such as antigen testing (26)(27)(28) or the use of antiviral drugs (29), which depend upon and/or affect the within-host dynamics in a manner that cannot be fully captured in simple population-level models. Multi-scale approaches have been applied to SARS-CoV-2 (26)(27)(28)(29)(30)(31)(32)(33) and other pathogens including influenza (23,34) to generate outbreak projections and test control interventions.…”

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

“…One advantage of such approaches is that they facilitate a detailed description of the impact of interventions, such as antigen testing (26)(27)(28) or the use of antiviral drugs (29), which depend upon and/or affect the within-host dynamics in a manner that cannot be fully captured in simple population-level models. Multi-scale approaches have been applied to SARS-CoV-2 (26)(27)(28)(29)(30)(31)(32)(33) and other pathogens including influenza (23,34) to generate outbreak projections and test control interventions. However, multi-scale methods have not previously been used to estimate the outbreak risk, or to analyse how the risk can be mitigated through pre-emptive interventions.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the risk and pre-emptive control of viral outbreaks accounting for within-host dynamics: SARS-CoV-2 antigen testing as a case study

Hart

Park

Jeong

et al. 2023

Preprint

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In the era of living with COVID-19, the risk of localised SARS-CoV-2 outbreaks remains. Here, we develop a multi-scale modelling framework for estimating the local outbreak risk for a viral disease (the probability that a major outbreak results from a single case introduced into the population), accounting for within-host viral dynamics. Compared to population-level models previously used to estimate outbreak risks, our approach enables more detailed analysis of how the risk can be mitigated through pre-emptive interventions such as antigen testing. Considering SARS-CoV-2 as a case study, we quantify the within-host dynamics using data from individuals with omicron variant infections. We demonstrate that regular antigen testing reduces, but may not eliminate, the outbreak risk, depending on characteristics of local transmission. In our baseline analysis, daily antigen testing reduces the outbreak risk by 45% compared to a scenario without antigen testing. Additionally, we show that accounting for heterogeneity in within-host dynamics between individuals affects outbreak risk estimates and assessments of the impact of antigen testing. Our results therefore highlight important factors to consider when using multi-scale models to design pre-emptive interventions against SARS-CoV-2 and other viruses.

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Faster detection of asymptomatic COVID-19 cases among care home staff in England through the combination of SARS-CoV-2 testing technologies

Ryan,

Cole-Hamilton,

Dandamudi

et al. 2024

Sci Rep

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To detect SARS-CoV-2 amongst asymptomatic care home staff in England, a dual-technology weekly testing regime was introduced on 23 December 2020. A lateral flow device (LFD) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) test were taken on the same day (day 0) and a midweek LFD test was taken three to four days later. We evaluated the effectiveness of using dual-technology to detect SARS-CoV-2 between December 2020 to April 2021. Viral concentrations derived from qRT-PCR were used to determine the probable stage of infection and likely level of infectiousness. Day 0 PCR detected 1,493 cases of COVID-19, of which 53% were in the early stages of infection with little to no risk of transmission. Day 0 LFD detected 83% of cases that were highly likely to be infectious. On average, LFD results were received 46.3 h earlier than PCR, enabling removal of likely infectious staff from the workplace quicker than by weekly PCR alone. Demonstrating the rapidity of LFDs to detect highly infectious cases could be combined with the ability of PCR to detect cases in the very early stages of infection. In practice, asymptomatic care home staff were removed from the workplace earlier, breaking potential chains of transmission.

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Modelling the impact of repeat asymptomatic testing policies for staff on SARS-CoV-2 transmission potential

Cited by 6 publications

References 61 publications

Pandemic Preparedness among Big Energy Companies: Call to Research and Action

Pandemic Preparedness among Big Energy Companies: Call to Research and Action

Analysis of the risk and pre-emptive control of viral outbreaks accounting for within-host dynamics: SARS-CoV-2 antigen testing as a case study

Faster detection of asymptomatic COVID-19 cases among care home staff in England through the combination of SARS-CoV-2 testing technologies

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