2023
DOI: 10.1111/bcp.15965
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Modelling the progression of illicit substance use patterns from real‐world evidence

Hari Prabhath Tummala,
Robert R. Bies,
Murali Ramanathan

Abstract: AimsTo investigate an innovative pharmacometrics approach that addresses the challenges of using real‐world evidence to model the progression of illicit substance use.MethodsThe modelling strategy analysed real‐world data from the National Longitudinal Study of Adolescent to Adult Health (AddHealth) survey using survival analyses and differential equations. Respondents were categorized into drug‐naïve, active users and nonusers. The transitions between categories were modelled using interval‐censored parametri… Show more

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“…Finally, the modelling of illicit substance abuse patterns among different age groups was undertaken by Tummala et al 13 They presented a detailed methodology that could inform clinical trial design and pharmacometrics models for substance use disorder treatments in the future.…”
mentioning
confidence: 99%
“…Finally, the modelling of illicit substance abuse patterns among different age groups was undertaken by Tummala et al 13 They presented a detailed methodology that could inform clinical trial design and pharmacometrics models for substance use disorder treatments in the future.…”
mentioning
confidence: 99%