2010
DOI: 10.1007/978-1-4419-6064-1_14
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Modelling the Transmission of Trypanosoma cruzi: The Need for an Integrated Genetic Epidemiological and Population Genomics Approach

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Cited by 18 publications
(11 citation statements)
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“…Although T. cruzi is potentially able to infect all mammalian species [16], according to the particularities of host, parasite genotype and their interactions, some species might maintain longer and/or higher parasitemias than others, which will probably reflect different potentials of these hosts to infect vectors and, thus, to serve as reservoirs in a particular intervals of time and space [17]. In this sense, the potential to infect vectors is directly related to the presence of trypomastigotes in the bloodstream of a given mammalian species, thus available to be taken up by the vector during its blood meal.…”
Section: Introductionmentioning
confidence: 99%
“…Although T. cruzi is potentially able to infect all mammalian species [16], according to the particularities of host, parasite genotype and their interactions, some species might maintain longer and/or higher parasitemias than others, which will probably reflect different potentials of these hosts to infect vectors and, thus, to serve as reservoirs in a particular intervals of time and space [17]. In this sense, the potential to infect vectors is directly related to the presence of trypomastigotes in the bloodstream of a given mammalian species, thus available to be taken up by the vector during its blood meal.…”
Section: Introductionmentioning
confidence: 99%
“…Variations in the clinical forms of Chagas disease and in the susceptibility/resistance of T. cruzi to specifi c treatment have been observed during evaluations of patients from distinct endemic regions 1,26 . These differences may be attributed to T. cruzi and host genetic diversity 10 in addition to environmental conditions, which were the same for all experimental groups in this study and were consequently not considered in our analyses 27 . These observations have prompted several research groups to isolate and characterize different samples of the parasite from distinct hosts and vectors species from domestic, peridomestic, and sylvatic environments [28][29][30][31] .…”
Section: Discussionmentioning
confidence: 99%
“…Finally, studies on genetic susceptibility of the host to infection by Chagas disease remain few and sparse even when considering the variation in transmission rates reported in different endemic populations, as recently reviewed by Tibayrenc (2010). Could host resistance to T. cruzi invasion or reduced severity of Chagas disease in some populations be related to variation in innate immune responses?…”
Section: Perspectivesmentioning
confidence: 99%