Modelling umbilical vein blood flow normograms at 14–40 weeks of gestation by quantile regression analysis

Rizzo, Giuseppe; Rizzo, Ludovica; Aiello, Elisa; Allegra, E; Arduini, Domenico

doi:10.3109/14767058.2015.1019855

Cited by 23 publications

(42 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25,44,45 Published data indicated that the largest umbilical vein diameter occurs during the third trimester, somewhere between 32 and 42 weeks GA. 50 The majority of published work over the last 17 years has modelled the relationship between the intra-abdominal or intra-amniotic umbilical vein velocity and GA as a positive linear trend, 12,[29][30][31]51 similar to that found in this research. 27,29,46 In this research, the diameter reached a peak value at 37 weeks GA and remained relatively stable until 40 weeks GA, before declining.…”

Section: Discussionsupporting

confidence: 74%

“…However, there is some variation in opinion as to whether this substantial increase continues up and past 40 weeks or whether there is a decline in the later weeks of pregnancy. 27,29,30 The decline after 40 weeks GA documented in this research for both the UCV diameter and Qucv may be the result of a small number of observations during the 40-42 week period. The reference range trend was very similar to that produced in pioneering work undertaken by Gill et al (1984).…”

Section: Discussionmentioning

confidence: 71%

“…8,27,[30][31][32] The intrasonographer and intersonographer reliabilities were tested on images from ten randomly selected participants. 8,27,[30][31][32] The intrasonographer and intersonographer reliabilities were tested on images from ten randomly selected participants.…”

Section: Ultrasound Examinationmentioning

confidence: 99%

“…UCV blood flow (ml/min) was calculated as Q UCV = p (diameter/2) 2 9 (0.5 9 UCV PV) 9 60 27-30 where 0.5 was the spatial velocity profile coefficient applicable to a parabolic profile and the UCV was assumed to be circular. 8,27,[30][31][32] The intrasonographer and intersonographer reliabilities were tested on images from ten randomly selected participants. Four sonographers undertook measurements of the diameter and PV three times for each stored image.…”

Section: Ultrasound Examinationmentioning

confidence: 99%

“…and Sutton et al; 26 while Boito et al collected to 36 weeks, 8 Barbera et al to 38 weeks 31 and others to 40 weeks GA 21,29,30. …”

mentioning

confidence: 99%

See 4 more Smart Citations

Reference ranges for the intra‐amniotic umbilical cord vein diameter, peak velocity and blood flow in a regional NSW population

Spurway

Logan

Pak

et al. 2017

Australas J Ultrason Med

View full text Add to dashboard Cite

Aim: To construct gestational age (GA)-related reference ranges of the intra-amniotic umbilical cord vein (UCV) diameter, peak velocity (PV) and blood flow (Qucv) using a Central West New South Wales population. Materials and Methods: This was a prospective, quasi-experimental study of low risk, singleton pregnancies (n = 321) between 16 and 42 weeks of gestation. Participation was voluntary following informed consent. The UCV diameter and PV were measured using B mode and duplex Doppler respectively, and Qucv calculated. Percentile values and reference range graphs were established using quantile regression modelling in R statistical software. Intraclass correlation coefficients (ICCs) were calculated to assess the intra and intersonographer reliability. Results: Reference ranges for the UCV diameter, PV and Qucv were established and graphed. All three UCV measurements increased with advancing GA, with both diameter and Qucv exhibiting a decline in the late third trimester. The intrasonographer and intersonographer ICCs for the UCV diameter and PV showed almost perfect agreement within and between sonographers. Conclusion: Gestational age-related reference ranges for the UCV diameter, PV and Qucv were developed using quantile regression from a cohort of low risk, singleton pregnancies in Central West NSW. These reference ranges have the potential to assist in the diagnosis and monitoring of fetal growth restriction.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 71%

Section: Ultrasound Examinationmentioning

confidence: 99%

Section: Ultrasound Examinationmentioning

confidence: 99%

“…and Sutton et al; 26 while Boito et al collected to 36 weeks, 8 Barbera et al to 38 weeks 31 and others to 40 weeks GA 21,29,30. …”

mentioning

confidence: 99%

See 3 more Smart Citations

Reference ranges for the intra‐amniotic umbilical cord vein diameter, peak velocity and blood flow in a regional NSW population

Spurway

Logan

Pak

et al. 2017

Australas J Ultrason Med

View full text Add to dashboard Cite

show abstract

The umbilical vein in the human fetus has a non‐linear growth pattern across gestation

Najafzadeh

Jacoby

Mattes

et al. 2016

Australas J Ultrasound Med

View full text Add to dashboard Cite

Introduction and Objectives: Estimation of the umbilical venous blood flow volume relies on the diameter of the vein, which has been reported to be reduced in severely growth restricted fetuses. However, there is only limited information on the growth pattern of this vessel in the normal human fetus. The aim of this study is to examine the growth pattern of the umbilical vein across gestation in low-risk human pregnancies. Methods: In a prospective, longitudinal ultrasound study of 136 low-risk pregnancies, the internal diameter of the intra-amniotic portion of the umbilical vein was measured at 18, 26 and 34 weeks of gestation. To investigate the growth pattern of the venous diameter, the ratios of diameters at 26 weeks to diameters at 18 weeks (ratio 1) and the ratios at 34 to 26 weeks (ratio 2) were also calculated. A paired-sample t-test was performed to compare the means of the two ratios. Results: The mean diameter of the umbilical vein at 18 weeks was 2.8 mm (SD 0.40), 5.8 mm (SD 0.67) at 26 weeks and 7.6 mm (SD 0.98) at 34 weeks. The mean of ratio 1 was 2.06 (95% CI 2.01-2.14), which was significantly higher than ratio 2 (mean 1.33, 95% CI 1.29-1.36), P < 0.001. Conclusion: The umbilical venous diameter demonstrates a non-linear growth pattern between 18 and 34 weeks of gestation. The diameter doubled in size between 18 and 26 weeks but grew at a slower rate between 26 and 34 weeks of gestation. This study provides new data on the normal growth pattern of the umbilical vein by identifying a period of gestation where its growth is accelerated.

show abstract

Umbilical vein blood flow: State‐of‐the‐art

Barbieri

Martino

Ferrazzi

et al. 2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

Placental blood supply to the fetus can be measured by evaluating the umbilical vein blood flow. Despite its potential application in healthcare, the umbilical vein blood flow volume is still used only in research setting. One of the reasons is a concern regarding its reproducibility, partly due to technology issues. Nowadays, technology improvements make this evaluation accurate and reproducible. The aim of this review is to refresh basic elements of the physiology of umbilical vein blood flow and its analysis. Its evaluation in normal and abnormal fetal growth is also discussed.

show abstract

Modelling umbilical vein blood flow normograms at 14–40 weeks of gestation by quantile regression analysis

Cited by 23 publications

References 22 publications

Reference ranges for the intra‐amniotic umbilical cord vein diameter, peak velocity and blood flow in a regional NSW population

Reference ranges for the intra‐amniotic umbilical cord vein diameter, peak velocity and blood flow in a regional NSW population

The umbilical vein in the human fetus has a non‐linear growth pattern across gestation

Umbilical vein blood flow: State‐of‐the‐art

Contact Info

Product

Resources

About