Modellvorstellungen zur Ätiopathogenese der Schizophrenien

Kornhuber, Johannes; Thome, Johannes; Riederer, Peter

doi:10.1007/978-3-7091-6458-7_1

Cited by 1 publication

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“…1) wobei Dopaminrezeptorantagonisten antipsychotisch wirken und partielle Glutamatagonisten vermutlich ebenfalls eine antipsychotische Wirkung haben [30,33,38].…”

Section: Biochemischeunclassified

Glutamaterge Neurotransmission bei Schizophrenien

Bleich

Bleich²,

Wiltfang³

et al. 2001

Fortschr Neurol Psychiatr

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Glutamate is the most abundant amino acid in the brain, where it plays an important role as a well-established major excitatory neurotransmitter in the central nervous system. It has been suggested that reduced glutamate neurotransmission may be involved in the pathophysiology of schizophrenia. The glutamate hypothesis of schizophrenia postulates alterations in the glutamatergic system as an important neurobiochemical event in the pathophysiology of this group of psychotic disorders. An altered glutamate release from synaptosomes including a hypofunction of different glutamate receptors (i.e. NMDA receptors) from different brain areas have previously been reported. Furthermore, partial agonists at the glycine co-agonist site of the NMDA receptor might be a new approach in the treatment of schizophrenic symptoms but further studies are necessary to clarify the role and efficacy of these substances in schizophrenia. Changes in the glutamatergic cortico-striatal connections in schizophrenia could precipitate a potential perceptive overstimulation of the neocortex from thalamic input and an inhibiting influence of the striatum on the thalamus would modulate the information input of the cortex, thereby possibly counteracting the disturbed information processing which is relatively characteristic for schizophrenic psychoses.

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“…1) wobei Dopaminrezeptorantagonisten antipsychotisch wirken und partielle Glutamatagonisten vermutlich ebenfalls eine antipsychotische Wirkung haben [30,33,38].…”

Section: Biochemischeunclassified