“…This paper reports the recent collaborative research effort between University of S. Paulo (USP) and University of Porto (UP). It draws heavily from the research work that has been taking place at UNESP and USP [9][10][11], with a significant collaboration with EMBRAPA, on optimizing the usage of multiple agrochemicals to control the proliferation of weeds (whose growth models exhibit resistance) to maximize the yield of crops. This experience, coupled with some optimal control theory developments, notably in optimal feedback control, infinite horizon optimal control, and Model Predictive Control [9,[12][13][14][15][16], at FEUP and UNESP, constitutes the basis for the optimal control framework proposed here.…”