Models of Chemical Communication for Micro/Nanoparticles

Ventura, Jordi; Llopis-Lorente, Antoni; Abdelmohsen, Loai K. E. A.; van Hest, Jan C. M.; Martínez-Máñez, Ramón

doi:10.1021/acs.accounts.3c00619

Cited by 5 publications

(2 citation statements)

References 60 publications

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“…Communication between cells is crucial to the survival of both unicellular and multicellular organisms. The primary mode of communication involves chemical cues. , A notable example is quorum sensing in bacteria, where chemical signals are both released and detected by cells to gauge population density, initiate collective migration, form multicellular assembly, etc. , There is great current interest in mimicking this behavior in synthetic cells to understand the physical basis of intercellular communication and design collective functional behavior. − For instance, enzymatic cascade was employed to facilitate the communication between two populations of synthetic cell, resulting in the production of fluorescent products . Additionally, this chemical communication serves as a bridge between synthetic cells and living organisms, potentially influencing the gene expressions and behaviors of living organisms. , …”

Section: Introductionmentioning

confidence: 99%

Chemomechanical Communication between Liposomes Based on Enzyme Cascades

Tseng,

Song,

Zhang

et al. 2024

J. Am. Chem. Soc.

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Communication between cells is crucial to the survival of both uni-and multicellular organisms. The primary mode of communication involves chemical cues. There is great current interest in mimicking this behavior in synthetic cells to understand the physical basis of intercellular communication and design collective functional behavior. Using liposomal cell mimics, we demonstrate how a chemical input can elicit a mechanical response (enhanced motility). We employed a single substrate to trigger enzyme cascade-induced control of the diffusion of up to three different liposome populations. Furthermore, substrate competition allows temporal control over enhanced diffusion. The use of enzyme cascades to propagate chemical signals provides a robust and efficient mechanism for diverse populations of protocells to coordinate their motion in response to signals from each other.

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Section: Introductionmentioning

confidence: 99%

Chemomechanical Communication between Liposomes Based on Enzyme Cascades

Tseng,

Song,

Zhang

et al. 2024

J. Am. Chem. Soc.

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“…In a recent report, the exchange of substrates between enzyme-functionalized liposomes was leveraged to induce enhanced motility of receivers . Yet, achieving programmability over the communication process to control collective behavior is still an underexplored field of science, which holds enormous potential toward the development of smart materials and synthetic tissues. For example, external control over the communication processes has been demonstrated via the use of light-activable ligands. , Control over protocell arrangements into microarrays has been achieved using acoustic trapping .…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures

Llopis-Lorente,

Shao,

Ventura

et al. 2024

ACS Cent. Sci.

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The spatiotemporal orchestration of cellular processes is a ubiquitous phenomenon in pluricellular organisms and bacterial communities, where sender cells secrete chemical signals that activate specific pathways in distant receivers. Despite its importance, the engineering and investigation of spatiotemporal communication in artificial cell consortia remains underexplored. In this study, we present spatiotemporal communication between cellular-scale entities acting as both senders and receivers. The transmitted signals are leveraged to elicit conformational alterations within compartmentalized DNA structures. Specifically, sender entities control and generate diffusive chemical signals, namely, variations in pH, through the conversion of biomolecular inputs. In the receiver population, compartmentalized DNA nanostructures exhibit changes in conformation, transitioning between triplex and duplex assemblies, in response to this pH variation. We demonstrate the temporal regulation of activated DNA nanostructures through the coordinated action of two antagonistic sender populations. Furthermore, we illustrate the transient distance-dependent activation of the receivers, facilitated by sender populations situated at defined spatial locations. Collectively, our findings provide novel avenues for the design of artificial cell consortia endowed with programmable spatiotemporal dynamics through chemical communication.

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Molecular Information Processing in a Chemical Reaction Network Using Surface‐Mediated Polyelectrolyte Complexation

Hazal Koyuncu,

Allegri,

Moazzenzade

et al. 2024

ChemSystemsChem

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Biochemical communication is ubiquitous in life. Biology use chemical reaction networks to regulate concentrations of myriad signaling molecules. Recent advances in supramolecular and systems chemistry demonstrate that feedback mechanisms of such networks can be rationally designed but strategies to transmit and process information encoded in molecules are still in their infancy. Here, we designed a polyelectrolyte reaction network maintained under out‐of‐equilibrium conditions using pH gradients in flow. The network, comprises two weak polyelectrolytes (polyallylamine, PAH, and polyacrylic acid, PAA) in solution and one immobilized on the surface (poly‐l‐lysine, PLL). We chose PAH and PAA as their complexation process is known to be history dependent (i.e., the preceding state of the system can determine the next state). Surprisingly, we found that the hysteresis diminished as the PLL‐coated surface supported rather than perturbed the formation of the complex. PLL‐coated surfaces are further exploited to established that reversible switching between the assembled and disassembled state of polyelectrolytes can exploited to process signals encoded in the frequency and duration of pH pulses. We envision that the strategy employed to modulate information in this polyelectrolyte reaction network could open novel routes to transmit and process molecular information in biologically relevant processes.

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Models of Chemical Communication for Micro/Nanoparticles

Cited by 5 publications

References 60 publications

Chemomechanical Communication between Liposomes Based on Enzyme Cascades

Chemomechanical Communication between Liposomes Based on Enzyme Cascades

Spatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures

Molecular Information Processing in a Chemical Reaction Network Using Surface‐Mediated Polyelectrolyte Complexation

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