Models of Endometriosis: Animal Models I – Rodent‐Based Chimeric Models

Bruner‐Tran, Kaylon L.; McConaha, Melinda E.; Osteen, Kevin G.

doi:10.1002/9781444398519.ch26

Cited by 5 publications

(3 citation statements)

References 118 publications

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“…Once human tissue is collected, it is disseminated via intraperitoneal or subcutaneous injection into the immunocompromised rodent. Heterologous rodent models with associated advantages and disadvantages have been described (Tirado-Gonzalez et al 2010, Bruner-Tran et al 2012, Grummer 2012, King et al 2015). …”

Section: Animal Research Modelsmentioning

confidence: 99%

Endometriosis: where are we and where are we going?

Greene¹,

Lang²,

Kendziorski³

et al. 2016

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Endometriosis currently affects ∼5.5 million reproductive-aged women in the U.S. with symptoms such as painful periods (dysmenorrhea), chronic pelvic pain, pain with intercourse (dyspareunia), and infertility. It is defined as the presence of endometrial tissue outside the uterine cavity and is found predominately attached to sites within the peritoneal cavity. Diagnosis for endometriosis is solely made through surgery as no consistent biomarkers for disease diagnosis exist. There is no cure for endometriosis and treatments only target symptoms and not the underlying mechanism(s) of disease. The nature of individual predisposing factors or inherent defects in the endometrium, immune system, and/or peritoneal cavity of women with endometriosis remains unclear. The literature over the last 5 years (2010-2015) has advanced our critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer. In this review, we cover the aforementioned topics with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometriosis research, while concluding with critical areas of endometriosis research that are urgently needed.

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Section: Animal Research Modelsmentioning

confidence: 99%

Endometriosis: where are we and where are we going?

Greene¹,

Lang²,

Kendziorski³

et al. 2016

Reproduction

146

106

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show abstract

“…We found that mice receiving resveratrol exhibited significantly fewer lesions, while lesions that were present were smaller and apoptotic. 33 Importantly, resveratrol did not appear to impact apoptotic activity within the uteri of treated mice. Although it is important to note that the doses used were pharmacologic and could not be obtained from normal consumption of resveratrol-containing foods, these data are promising and may suggest a potential role for resveratrol supplementation in the treatment of endometriosis in women.…”

Section: Introductionmentioning

confidence: 92%

“…24 Since progesterone is a potent differentiation agent, we have found that short-term treatment of mice bearing normal endometrial xenografts with the synthetic progestin medroxyprogesterone acetate led to stromal cell decidualization within human tissues. 33 However, longer-term treatment with this compound eliminates disease established by normal tissues. 29 These studies suggest that endometrial tissues, growing at an ectopic site in the peritoneum of nude mice, largely retain a similar level of responsiveness to progesterone that would be observed within the normal eutopic endometrium.…”

Section: Introductionmentioning

confidence: 99%

Novel Therapies Targeting Endometriosis

et al. 2011

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Endometriosis is an often painful disorder in which the endometrial glands and stroma grow outside the uterus. The disease affects women's quality of life and is a common cause of infertility. In this review, we describe promising new developments in the field based on in vitro assays and rodent models, each of which has the potential to be beneficial in the treatment of this disease. We will specifically describe the role of anti-inflammatory drugs, selective estrogen, or progesterone modulators, statins, antiangiogenic agents, and the potential for targeting stem cells as likely methods to hone in and eliminate endometriosis. The most promising of these potential therapies are currently slated for further testing in both rodent and nonhuman primate trials.

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Endometriosis

Zondervan

Becker

Koga

et al. 2018

Nat Rev Dis Primers

904

746

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Endometriosis is a common inflammatory disease characterized by the presence of tissue outside the uterus that resembles endometrium, mainly on pelvic organs and tissues. It affects ~5-10% of women in their reproductive years - translating to 176 million women worldwide - and is associated with pelvic pain and infertility. Diagnosis is reliably established only through surgical visualization with histological verification, although ovarian endometrioma and deep nodular forms of disease can be detected through ultrasonography and MRI. Retrograde menstruation is regarded as an important origin of the endometrial deposits, but other factors are involved, including a favourable endocrine and metabolic environment, epithelial-mesenchymal transition and altered immunity and inflammatory responses in genetically susceptible women. Current treatments are dictated by the primary indication (infertility or pelvic pain) and are limited to surgery and hormonal treatments and analgesics with many adverse effects that rarely provide long-term relief. Endometriosis substantially affects the quality of life of women and their families and imposes costs on society similar to those of other chronic conditions such as type 2 diabetes mellitus, Crohn's disease and rheumatoid arthritis. Future research must focus on understanding the pathogenesis, identifying disease subtypes, developing non-invasive diagnostic methods and targeting non-hormonal treatments that are acceptable to women who wish to conceive.

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Models of Endometriosis: Animal Models I – Rodent‐Based Chimeric Models

Cited by 5 publications

References 118 publications

Endometriosis: where are we and where are we going?

Endometriosis: where are we and where are we going?

Novel Therapies Targeting Endometriosis

Endometriosis

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