2016
DOI: 10.1016/j.jneumeth.2015.09.023
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Models of hypoxia and ischemia-induced seizures

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Cited by 60 publications
(86 citation statements)
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References 111 publications
(213 reference statements)
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“…This adaptive mechanism was absent under conditions of pure 9% hypoxia. Moreover, combined to the unexpected brain alkalosis which we observed immediately in response to pure hypoxia, these data show that exposure of an infant rodent to hypoxia 32,38 does not reproduce the physiological responses to asphyxia. Finally, we demonstrate that Graded Restoration of Normocapnia (GRN) following asphyxia, a putative therapeutic strategy, 39 slows down the pro-excitatory recovery of brain pH and extends the duration of the post-asphyxia P O 2 overshoot.…”
Section: Introductionmentioning
confidence: 74%
“…This adaptive mechanism was absent under conditions of pure 9% hypoxia. Moreover, combined to the unexpected brain alkalosis which we observed immediately in response to pure hypoxia, these data show that exposure of an infant rodent to hypoxia 32,38 does not reproduce the physiological responses to asphyxia. Finally, we demonstrate that Graded Restoration of Normocapnia (GRN) following asphyxia, a putative therapeutic strategy, 39 slows down the pro-excitatory recovery of brain pH and extends the duration of the post-asphyxia P O 2 overshoot.…”
Section: Introductionmentioning
confidence: 74%
“…The lack of sensitivity for hippocampal injury in our study likely influenced our ability to detect an association with seizure occurrence. Interestingly, animal studies of neonatal HIE demonstrate a significant increase in hippocampal mossy fiber sprouting, which has a possible role in subsequent epileptogenesis . Additional studies are needed to evaluate if DTI changes in the hippocampus are associated with seizure presence or persistence beyond the neonatal period.…”
Section: Discussionmentioning
confidence: 99%
“…Although seizures occur in animals subject to ongoing hypoxia and/or ischemia, it is difficult to relate these phenomena to clinical practice. Seizures do not occur during resuscitation or acute endovascular treatment of stroke .…”
Section: Discussionmentioning
confidence: 99%
“…Here we test the effects of OGD on recurrent seizure activity and neuronal chloride concentration in a spontaneously epileptic in vitro preparation, the organotypic hippocampal slice culture preparation . This in vitro preparation permits the study of OGD that is more severe than can be survived by in vivo experimental preparations subject to global hypoxia and ischemia . Reperfusion is also more feasible in vitro than in vivo .…”
Section: Introductionmentioning
confidence: 99%