Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential

Yamaguchi, Yuji; Nishio, Hitoshi; Kimura, Tadashi; Ackerman, S.J.; Koyanagi, H; Suda, Toshio

doi:10.1038/sj.leu.2401115

Cited by 14 publications

(3 citation statements)

References 47 publications

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“…HL60 cells can additionally differentiate towards eosinophils or basophils [19][20][21][22]. HT93 cells show eosinophil-neutrophil bipotency; YJ cells eosinophilneutrophil-monocyte tripotency [23]; and HAFTL-1 and 70Z/3 cells monocyte-B lymphocyte bipotency [24,25]. [2]).…”

Section: Early Models Of Hematopoiesismentioning

confidence: 99%

The sequential determination model of hematopoiesis

Brown¹,

Hughes²,

Michell³

et al. 2007

Trends in Immunology

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Section: Early Models Of Hematopoiesismentioning

confidence: 99%

The sequential determination model of hematopoiesis

Brown¹,

Hughes²,

Michell³

et al. 2007

Trends in Immunology

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“…Retinoic acid variably affected production of IgE (5,47,54) and generally inhibited mast cell (1a, 18, 19, 24), basophil, and eosinophil (12,26,35,55) growth and function. Furthermore, ATRA inhibited IL4-induced eotaxin-1 (CCL11) production in a human bronchial epithelial cell line (46), and VA inhibited Sephadex-induced eotaxin production in the lungs of rats (48); however, it increased IL4-and IL13-induced production of CCL11 and eotaxin 3 (CCL26) in primary bronchial epithelial cells.…”

mentioning

confidence: 99%

Localized Th1-, Th2-, T Regulatory Cell-, and Inflammation-Associated Hepatic and Pulmonary Immune Responses inAscaris suum-Infected Swine Are Increased by Retinoic Acid

et al. 2009

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Pigs infected with Ascaris suum or controls were given 100 g (low-dose) or 1,000 g (high-dose) all-trans retinoic acid (ATRA)/kg body weight in corn oil or corn oil alone per os on days after inoculation (DAI) ؊1, ؉1, and ؉3 with infective eggs. Treatment with ATRA increased interleukin 4 (IL4) and IL12p70 in plasma of infected pigs at 7 DAI and augmented bronchoalveolar lavage (BAL) eosinophilia observed at 7 and 14 DAI. To explore potential molecular mechanisms underlying these observations, a quantitative real-time reverse transcription (RT)-PCR array was used to examine mRNA expression in tissue. Ascaris-infected pigs had increased levels of liver mRNA for T-helper-2 (Th2)-associated cytokines, mast cell markers, and T regulatory (Treg) cells, while infected pigs given ATRA had higher IL4, IL13, CCL11, CCL26, CCL17, CCL22, and TPSB1 expression. Gene expression for Th1-associated markers (IFNG, IL12B, and TBX21), the CXCR3 ligand (CXCL9), IL1B, and the putative Treg marker TNFRSF18 was also increased. Expression of IL4, IL13, IL1B, IL6, CCL11, and CCL26 was increased in the lungs of infected pigs treated with ATRA. To determine a putative cellular source of eosinophil chemoattractants, alveolar macrophages were treated with IL4 and/or ATRA in vitro. IL4 induced CCL11, CCL17, CCL22, and CCL26 mRNA, and ATRA increased the basal and IL4-stimulated expression of CCL17 and CCL22. Thus, ATRA augments a diverse Th1-, Th2-, Treg-, and inflammation-associated response in swine infected with A. suum, and the increased BAL eosinophilia may be related to enhanced induction of eosinophil chemokine activity by alveolar macrophages.

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“…Since YJ cells express EPO [31], YJ cells were used to determine whether TauBr that is intracellularly synthesized modifi es IκBα, as does extracellularly administered TauBr. To defi ne the effect of TauBr, it is essential to distinguish the activities of MPO and EPO.…”

Section: Treatment Of Yj Cells With H 2 Omentioning

confidence: 99%