Models of Protein Metabolism

Hasselgren, Per-Olof J.; Fischer, David; Pritts, Timothy A.

doi:10.1016/b978-012655330-7/50062-9

Surgical Research 2001

DOI: 10.1016/b978-012655330-7/50062-9

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Models of Protein Metabolism

Per-Olof J. Hasselgren

David Fischer

Timothy A. Pritts

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“…Severe injury, infection, and sepsis are associated with multiple metabolic changes, affecting protein, carbohydrate, and lipid metabolism throughout the body [1,2,3,4]. One of the most significant metabolic changes that occur in these conditions is the catabolic response in skeletal muscle [5,6].…”

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Catabolic Response to Stress and Injury: Implications for Regulation

Hasselgren

2000

World j. surg.

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Muscle catabolism is an important component of the metabolic response to stress and injury, including sepsis and burn injury. Muscle wasting and weakness in catabolic patients may adversely affect the outcome in these patients owing to delayed ambulation and involvement of respiratory muscles. An understanding of the regulation of muscle protein breakdown during sepsis and following injury therefore is of great importance from a clinical standpoint and is essential for the development of new therapeutic modalities to prevent protein loss from muscle tissue. Studies in experimental animals and in patients have provided evidence that the myofibrillar proteins actin and myosin are particularly sensitive to the effects of sepsis and injury. (Glucocorticoids, interleukin-1, and tumor necrosis factor participate in the regulation of muscle protein breakdown. Most muscle proteins are degraded by the ubiquitin-proteasome-dependent proteolytic pathway. Because the proteasome does not degrade intact myofibrils, a calcium-dependent Z-band disintegration and release of myofilaments from the myofibrils may be an important initial step of muscle breakdown during sepsis and other catabolic conditions. Continued studies to define mechanisms of the catabolic response to stress and injury are important for improving the metabolic care of patients with muscle catabolism.

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confidence: 99%

“…Some of these products reach the liver via the portal vein and may participate in the regulation of the hepatic response to injury and sepsis. Metabolic consequences of stress and injury in tissues other than skeletal muscle are reviewed in greater detail elsewhere [1,2,3,4].…”

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confidence: 99%

Catabolic Response to Stress and Injury: Implications for Regulation

Hasselgren

2000

World j. surg.

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Models of Protein Metabolism

Cited by 1 publication

References 65 publications

Catabolic Response to Stress and Injury: Implications for Regulation

Catabolic Response to Stress and Injury: Implications for Regulation

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