Moderate alcohol consumption and adverse drug reactions among older adults

Onder, Graziano; Landi, Francesco; Vedova, Cecilia Della; Atkinson, Hal H.; Pedone, Claudio; Cesari, Matteo; Bernabei, Roberto; Gambassi, Giovanni

doi:10.1002/pds.721

Cited by 67 publications

(74 citation statements)

References 42 publications

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“…A third study among a sample of 667 communitydwelling older adults (mean [SD] age, 74 [7] years) living in northeast New York estimated that 25% of them drank alcohol and took medication that could negatively interact with alcohol [67]. A fourth study, using data from the Italian Group of Pharmacoepidemiology in the Elderly study, found that the prevalence of adverse drug reactions among 22,778 older hospitalized persons (mean [SD] age, 70 [16] years) was 3.7% among abstainers and 4.1% among those who drank < 40 g of alcohol per day [68]. After adjusting for potential confounders, moderate drinkers were 24% more likely to experience an adverse drug reaction compared with abstainers.…”

Section: Interaction With Medicationsmentioning

confidence: 99%

Alcohol and older people from a public health perspective

Anderson

Scafato

Galluzzo

2012

Annali Dell'Istituto Superiore Di Sanità

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Abstract. Objectives and methods. As part of the European project VINTAGE, a systematic review of scientific literature was undertaken to document the evidence base on the impact of alcohol on the health and well-being of older people, and on effective policies and preventive approaches to face the problem in this steadily increasing segment of the population. Results. 369 references were identified, from which 78 papers were selected. Conclusions. The review confirms the paucity of data on this topic and the need for more specific research. Although there is scarce evidence, the elderly seems to respond equally well to alcohol policy, screening instruments and brief interventions as do younger adults. According to a lifecycle approach, a future focus on the middle aged is also recommended.Key words: aged, alcohol drinking, public health, Europe, review.Riassunto (alcol e anziani in una prospettiva di salute pubblica). Obiettivi e Metodi. Nell'ambito del progetto europeo VINTAGE, è stata condotta una revisione sistematica della letteratura scientifica, al fine di fornire la base di evidenza sull'impatto del consumo di alcol sulla salute e il benessere degli anziani, e su misure e interventi di prevenzione efficaci nel fronteggiare il problema in questo segmento della popolazione in costante aumento. Risultati. Dai 369 riferimenti bibliografici identificati, sono stati selezionati 78 articoli. Conclusioni. La revisione conferma la carenza di dati sull'argomento e la necessità di ricerche mirate. Nonostante la scarsità di evidenze, sembra che gli anziani rispondano altrettanto bene degli adulti alle politiche sull'alcol, agli strumenti di screening e all'intervento breve. In un'ottica che investe l'intero arco della vita, si raccomanda di focalizzare gli interventi futuri anche sugli adulti.Parole chiave: anziani, assunzione di alcolici, salute pubblica, Europa, rassegna.

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Section: Interaction With Medicationsmentioning

confidence: 99%

Alcohol and older people from a public health perspective

Anderson

Scafato

Galluzzo

2012

Annali Dell'Istituto Superiore Di Sanità

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“…The article concludes with the idea that even though pharmacists are aware of ADRs and their rates, they need to further 20 stress the importance of actually reporting incidents of ADRs so both doctors and patients can be made more aware of their prevalence. It is noted that the actual rates of ADRs in retail-chain pharmacies vary between 1.8% and 6.7% depending on the study conducted (Bond and Raehl, 2006, Pirmohamed, 2004, Onder, et al, 2008, Lazarou, 1998. While these numbers may seem small, they still mean that up to 1 in 16 patients will experience some kind of adverse drug reaction after receiving and taking their drugs from the retail pharmacy.…”

Section: Decrease In Pharmacist-patient Counseling and Relationship Tmentioning

confidence: 99%

“…First, automation in the form of script-filling machinery and electronic systems such as computer databases is prevalent in corporatized pharmacies (Bush et al, 2008). Corporatization is also associated with other changes including increases in efficiency of workflow, reduced staffing and increases in ADR rates (Green et al, 2011, Onder et al, 2008. 'Compliance' otherwise referred to as 'adherence' or 'concordance' is defined generally by the World Health Organization (WHO) as: "The extent to which a person's behavior -taking medications, following a diet, and/or executing lifestyle changes, corresponds with agreed recommendations from a health care provider" (WHO, 2003).…”

Section: Introductionmentioning

confidence: 99%

The Corporatization of Retail Pharmacy: Changes in Efficacy, Reliability, and Expedience

Bodreau¹

2015

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The retail pharmacy of the present has undergone a large shift in ownership from private to corporate in the form of chain pharmacies. In this literature review, the effects of this shift in ownership, otherwise referred to as "corporatization" are examined in order to determine both the benefits and areas of concern regarding this change. This review suggests that the benefits include: Decreases in filling time and increases in patients of satisfaction. The areas of concern include: Decreasing patient-pharmacist counseling rates, increases in Adverse Drug Reaction rates and decreased pharmacy costs but not patient costs. It is concluded that the areas of concern outweigh the potential benefits. In order to improve on these areas of concern regarding corporatized pharmacies several changes must be made. First, pharmacists must be educated on proper counseling techniques in reduced time-frame to ensure patient understanding of medication. Second, these pharmacies should consider more staffing to ensure that patientpharmacist counseling times don't decrease more. Finally, more research needs to be done into the specific effects of corporatization in order to draw a more robust and complete conclusion on its overall effects on the retail pharmacy.

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“…Data were analyzed by binary logistic regression applying stepwise backward selection using presence or absence of ADEs as the dependent variable. In the primary analysis, the independent variables included age, sex, number of prescribed medications, Charlson Comorbidity Index [28] and dementia diagnosis (possible or probable Alzheimer's disease, other dementing illness, mild cognitive impairment), which have previously been shown to be independent predictors of ADEs [32][33][34] . Additional independent variables entered into the model included MMSE (total score), baseline use of NHPs, years of education, and race (Caucasian or non-Caucasian).…”

Section: Discussionmentioning

confidence: 99%

Adverse Drug Events in Cognitively Impaired Elderly Patients

Ganjavi¹,

Herrmann²,

Rochon³

et al. 2007

Dement Geriatr Cogn Disord

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Background/Aims: Adverse drug events (ADEs) are a frequent problem encountered in the elderly. The aim of this study was to elucidate the factors that influence ADEs in an elderly population with cognitive impairment. Methods: 242 patients were recruited from dementia clinics and assessed after 6 months for ADEs. The use of natural health products (NHPs) was also documented. Results: Backward logistic regression found that higher age (OR = 1.06; 95% CI 1.01–1.12), and greater cognitive impairment (OR = 0.94; 95% CI 0.90–0.98) were associated with an increased risk of developing an ADE while the use of NHPs (OR = 0.32; 95% CI 0.13–0.79) was associated with a decreased risk (χ² = 27.6, p < 0.001). Conclusion: Risk of ADEs increased with greater age and cognitive impairment but decreased with the use of NHPs.

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Moderate alcohol consumption and adverse drug reactions among older adults

Abstract: Moderate alcohol intake is associated with an increased risk of ADRs; this effect seems more evident among women than men, and it does not differ across age groups.

Cited by 67 publications

References 42 publications

Alcohol and older people from a public health perspective

Alcohol and older people from a public health perspective

The Corporatization of Retail Pharmacy: Changes in Efficacy, Reliability, and Expedience

Adverse Drug Events in Cognitively Impaired Elderly Patients

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