Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

Hartman, Terryl J.; Baer, David J.; Graham, Louella W.; Stone, William L.; Gunter, Elaine W.; Parker, Carol E.; Albert, Paul S.; Dorgan, Joanne F.; Clevidence, Beverly A.; Campbell, William H.; Tomer, Kenneth B.; Judd, Joseph T.; Taylor, Philip R.

doi:10.1038/sj.ejcn.1602051

Cited by 39 publications

(23 citation statements)

References 37 publications

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“…In accordance with this, elevated levels of isoprostanes have been detected in situations associated with increased free radical generation, in HIV-1-infected individuals, in postmenopausal women, and in chronic cigarette smokers (33,53). Similarly, increased production of arachidonic acid from different sources associated with various pathological conditions has been reported (47).…”

Section: Coculturing Of Infected T Cells With Neurons or Neurons Exposupporting

confidence: 52%

“…The detection of isoprostanes in vivo is used as a quantitative index for the existence of oxidative stress and also as a biomarker for certain types of diseases, such as cancer (33,79). In accordance with this, elevated levels of isoprostanes have been detected in situations associated with increased free radical generation, in HIV-1-infected individuals, in postmenopausal women, and in chronic cigarette smokers (33,53).…”

Section: Coculturing Of Infected T Cells With Neurons or Neurons Expomentioning

confidence: 99%

“…Besides Hsp70 levels, we also determined the levels of 8-iso-PGF-2␣, a major isoprostane, and a universally accepted oxidative stress marker produced by the nonenzymatic free radical-induced peroxidation of arachidonic acid present in phospholipids (55). The increased production of 8-iso-PGF-2␣ is usually associated with pathological conditions known to involve a heightened state of oxidative stress (33,79). Coculturing of HIV-1-infected monocytes or T cells with postmitotically differentiated neurons with or without alcohol was performed as described above.…”

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confidence: 99%

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Cholesterol-Depleting Statin Drugs Protect Postmitotically Differentiated Human Neurons against Ethanol- and Human Immunodeficiency Virus Type 1-Induced Oxidative Stress In Vitro

Acheampong

Parveen

Mengistu

et al. 2007

J Virol

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The AIDS-related dementia characterized by cognitive dysfunction, motor neuron disease, coordination abnormalities, and other neurological signs and symptoms develops in many human immunodeficiency virus type 1 (HIV-1)-infected individuals (17, 58). The molecular mechanisms involved in these HIV-1-associated dysfunctions of the central nervous system (CNS) remain incompletely explained and controversial (42,45). Studies have demonstrated that although the major reservoirs for productive infection within the CNS of HIV-1-infected individuals are microglia and monocytes/macrophages, infection of other CNSbased cell types, such as microvascular endothelial cells and neurons, also appears to occur (44,57,92). The role of lymphocytes in AIDS dementia has also been described previously (59,67,68). Of note, viral replication in cerebrospinal fluid is considered to be a marker for the severity of AIDS-related neurodegeneration (16,20). The CNS tissues are protected from the periphery by a structure known as blood-brain barrier (BBB), which limits the passage of solutes as well as infections into the brain (10). The tight junctions of brain microvascular endothelial cells strengthen the functional impermeability of BBB. Under certain pathological conditions, the BBB becomes compromised, providing access for infections/infected cells into the brain (64). The passage of HIV-1 entry into the brains of AIDS patients in vivo is not quite clear and is supposed to involve both free viruses and virally infected cells (4,89,91).HIV-1-infected individuals are under chronic oxidative stress, and antioxidants have proved to ameliorate infectionassociated oxidative stress. (81, 84). Oxidative stress involves

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Section: Coculturing Of Infected T Cells With Neurons or Neurons Exposupporting

confidence: 52%

Section: Coculturing Of Infected T Cells With Neurons or Neurons Expomentioning

confidence: 99%

mentioning

confidence: 99%

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Cholesterol-Depleting Statin Drugs Protect Postmitotically Differentiated Human Neurons against Ethanol- and Human Immunodeficiency Virus Type 1-Induced Oxidative Stress In Vitro

Acheampong

Parveen

Mengistu

et al. 2007

J Virol

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“…In addition, recent studies have consistently shown that red wine and white wine also have beneficial effects in vivo on blood antioxidant activity (71,72,75,159). However, alcohol has also been found to exhibit a pro-oxidant effect (72,74,160). Some studies suggest that the antioxidant or pro-oxidant activities of alcoholic beverages may depend on factors, such as dose, ethanol content, polyphenol content, ethanol metabolism, and cell type (73,(161)(162)(163)(164)(165), but this is still unclear.…”

Section: Epidemiology Of Breast Cancer: Role Of Lipid Peroxidationmentioning

confidence: 99%

Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer

Gago‐Dominguez

Castelao

Pike

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We have recently proposed a common mechanistic pathway by which obesity and hypertension lead to increased renal cell cancer risk. Our hypothesis posits lipid peroxidation, which is a principal mechanism in rodent renal carcinogenesis, as an intermediate step that leads to a final common pathway shared by numerous observed risks (including obesity, hypertension, smoking, oophorectomy/hysterectomy, parity, preeclampsia, diabetes, and analgesics) or protective factors (including oral contraceptive use and alcohol) for renal cell cancer [Cancer Causes Control 2002;13:287 -93]. During this exercise, we have noticed how certain risk factors for renal cell carcinoma are protective for breast cancer and how certain protective factors for renal cell carcinoma increase risk for breast cancer. Parity and oophorectomy, for example, are positively associated with renal cell carcinoma but are negatively associated with breast cancer. Similarly, obesity and hypertension are positively associated with renal cell carcinoma, but obesity is negatively associated with breast cancer in premenopausal women and hypertension during pregnancy is negatively associated with breast cancer. Furthermore, alcohol intake, negatively associated with renal cell carcinoma, is also positively associated with breast cancer. We propose here the possibility that lipid peroxidation may represent a protective mechanism in breast cancer. Although this runs counter to the conventional view that lipid peroxidation is a process that is harmful and carcinogenic, we present here the chemical and biological rationale, based on epidemiologic and biochemical data, which may deserve further consideration and investigation. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2829 -39)

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“…Several previous studies have applied urinary isoprostane as biomarkers of oxidative stress in general. The formation of isoprostane is related to personal factors (age) (Dohi et al, 2007), occupational exposure (welding fume) (Han et al, 2005), life style (vitamin C, vitamin E supplementation (Huang et al, 2002), smoking, (Dietrich et al, 2002;Dietrich et al, 2003), vegetable and fruit intake (Thompson et al, 2005), and alcohol consumption (Hartman et al, 2005), and occurrence of chronic diseases (asthma, atherosclerosis, ischemia-reperfusion, cardiovascular disease (Cracowski, 2004), systemic lupus erythematosus, inflammatory rheumatic disease, diabetes mellitus (Cracowski et al, 2002), and breast cancer (Rossner et al, 2006). Il'yasova et al (2004) indicated that ELISA measurements overestimates F2-Isoprostane levels than the GC/MS measurements.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Polycyclic Aromatic Hydrocarbons Associated with Traffic Exhaust: The Increase of Lipid Peroxidation and Reduction of Antioxidant Capacity

Lai

Liou

Jaakkola

et al. 2012

Aerosol Air Qual. Res.

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This study was carried out to examine the association between exposure to polycyclic aromatic hydrocarbon with traffic exhaust and biomarkers of lipid peroxidation and antioxidant levels among highway toll station workers. We conducted a cross-sectional study of 47 female highway toll station workers exposed to traffic exhausts and 27 female classroom trainees as a reference group. Exposure assessment was based on a biomarker of polycyclic aromatic hydrocarbon exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary isoprostane was assayed as a biomarker of lipid peroxidation, and plasma antioxidative capacity of lipid-soluble substances (ACL) and water-soluble substances (ACW) was measured. The median concentration of urinary isoprostane was higher among the exposed non-smokers (4.63 ng/mL) compared with the reference non-smokers (3.52 ng/mL, difference: 0.91, 95% CI -0.15 to 1.98) (Wilcoxon rank-sum test: p = 0.04). The median concentration of ACW among non-smoking exposed subjects (37.9 μg/mL Trolox equivalent) was lower than that of the reference non-smokers (86.3 μg/mL). Adjusting for confounding effects by linear regression, a change in log(isoprostane) concentration was significantly related to a unit change in log(1-OHPG) (regression coefficient [ß], β = 0.14, 95% CI 0.07 to 0.21). Exposure to polycyclic aromatic hydrocarbon is associated with increased lipid peroxidation and reduced antioxidative capacity in toll station workers.

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Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

Cited by 39 publications

References 37 publications

Cholesterol-Depleting Statin Drugs Protect Postmitotically Differentiated Human Neurons against Ethanol- and Human Immunodeficiency Virus Type 1-Induced Oxidative Stress In Vitro

Cholesterol-Depleting Statin Drugs Protect Postmitotically Differentiated Human Neurons against Ethanol- and Human Immunodeficiency Virus Type 1-Induced Oxidative Stress In Vitro

Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer

Exposure to Polycyclic Aromatic Hydrocarbons Associated with Traffic Exhaust: The Increase of Lipid Peroxidation and Reduction of Antioxidant Capacity

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