Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

Hodges, Joanna; Maiz, Maria; Cao, Sisi; Lachcik, Pamela J.; McCabe, George P.; McCabe, Linda D; Cladis, Dennis P.; Jackson, George S.; Ferruzzi, Mario G.; Lila, Mary Ann; Bailey, Regan L; Martin, Berdine R.; Weaver, Connie M.

doi:10.1016/j.ajcnut.2023.05.033

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Interestingly, diet treatment did not affect bone mass, where an increase in bone mass would have been expected with the HFD-fed animals compared to the HFEB-fed animals because of the 34% increase in body weight. There is recent evidence that berry and plum anthocyanins may promote bone remodeling. − Putative effects of elderberry treatment on increased bone mass in normal-weight mice require additional study.…”

Section: Discussionmentioning

confidence: 99%

Diet-Induced Rodent Obesity Is Prevented and the Fecal Microbiome Is Improved with Elderberry (Sambucus nigra ssp. canadensis) Juice Powder

Minj,

Riordan,

Teets

et al. 2024

J. Agric. Food Chem.

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Anthocyanin-rich edible berries protect against diet-induced obesity in animal models. Prevention is mediated through the bidirectional relationship with the fecal microbiome, and gut-derived phenolic metabolite absorption increases with physical activity, which may influence bioactivity. The objective of this study was to test elderberry juice powder on the development of diet-induced obesity and its influence on the fecal microbiome alone or in combination with physical activity. Male C57BL/6J mice were assigned to one of four treatments, including (1) high-fat diet without wheel access; (2) high-fat diet with unlimited wheel access; (3) high-fat diet supplemented with 10% elderberry juice powder without wheel access; and (4) high-fat diet supplemented with 10% elderberry juice powder with unlimited wheel access. Body weight gain, fat pads, and whole-body fat content in mice fed elderberry juice were significantly less than in mice fed the control diet independent of wheel access. At the end of the study, active mice fed elderberry juice ate significantly more than active mice fed a control diet. There was no difference in the physical activity between active groups. Elderberry juice increasedBifidobacterium, promotedAkkermansia and Anaeroplasma, and prevented the growth of Desulfovibrio. Elderberry juice is a potent inhibitor of diet-induced obesity with action mediated by the gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Diet-Induced Rodent Obesity Is Prevented and the Fecal Microbiome Is Improved with Elderberry (Sambucus nigra ssp. canadensis) Juice Powder

Minj,

Riordan,

Teets

et al. 2024

J. Agric. Food Chem.

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“…The medium dose of blueberry powder reduced serum concentrations of RANKL by 14% ( p < 0.05), and all doses of blueberry powder decreased concentrations of serum P1NP by a mean of 26% ( p < 0.01). No statistically significant relationships were found between the treatment and RANKL/OPG ratio, and markers of bone resorption (sclerostin, OPG, CTX-II, urinary NTx normalized to creatinine) [ 214 ]; see Table 3 .…”

Section: Functional Foods With Impact On Healthmentioning

confidence: 99%

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

Faienza,

Giardinelli,

Annicchiarico

et al. 2024

IJMS

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Bone health is the result of a tightly regulated balance between bone modeling and bone remodeling, and alterations of these processes have been observed in several diseases both in adult and pediatric populations. The imbalance in bone remodeling can ultimately lead to osteoporosis, which is most often associated with aging, but contributing factors can already act during the developmental age, when over a third of bone mass is accumulated. The maintenance of an adequate bone mass is influenced by genetic and environmental factors, such as physical activity and diet, and particularly by an adequate intake of calcium and vitamin D. In addition, it has been claimed that the integration of specific nutraceuticals such as resveratrol, anthocyanins, isoflavones, lycopene, curcumin, lutein, and β-carotene and the intake of bioactive compounds from the diet such as honey, tea, dried plums, blueberry, and olive oil can be efficient strategies for bone loss prevention. Nutraceuticals and functional foods are largely used to provide medical or health benefits, but there is an urge to determine which products have adequate clinical evidence and a strong safety profile. The aim of this review is to explore the scientific and clinical evidence of the positive role of nutraceuticals and functional food in bone health, focusing both on molecular mechanisms and on real-world studies.

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“…209 A dose-response study of bone calcium retention among 19 postmenopausal women given blueberries showed a hormetic effect-that is, a stronger benefit at lower (0.75 or 1.5 cup equivalents/ d) than higher (3 cup equivalents/d) doses. 210 Metabolites arising from bacterial fermentation of polyphenolics may be, Bold Prebiotics and probiotics at least in part, responsible for the bone-protective effects of polyphenol-rich foods. 211 Prebiotics and probiotics have the general advantage of being better defined than natural plant foods, especially if manufactured by a standardized protocol.…”

Section: Dietary Bioactivesmentioning

confidence: 99%

“…One study in 160 women showed more pronounced effects at the spine and ulna, 208 whereas another study in 235 women showed the most benefit to the total hip 209 . A dose-response study of bone calcium retention among 19 postmenopausal women given blueberries showed a hormetic effect—that is, a stronger benefit at lower (0.75 or 1.5 cup equivalents/d) than higher (3 cup equivalents/d) doses 210 . Metabolites arising from bacterial fermentation of polyphenolics may be, Bold Prebiotics and probiotics at least in part, responsible for the bone-protective effects of polyphenol-rich foods 211 …”

Section: Diet and Bone Healthmentioning

confidence: 99%

Sorting Dietary Advice for Bone Health

Weaver,

Wallace,

Cao

2024

Nutr Today

Self Cite

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Healthcare professionals are consistently bombarded with conflicting messages about the role of diet in bone health. Yet, few resources are available that compile the broad scope of dietary factors that influence bone health. This article evaluates the evidence on the association of diet and exercise with bone health, with the aim to provide a resource for healthcare professionals and researchers in the field. This review also highlights gaps in knowledge, provides dialogue around why some studies exhibit conflicting outcomes, and showcases why many remaining questions likely cannot be answered with the current evidence to date. The best evidence to date supports obtaining recommended dairy and calcium intakes for building bone in early life and mitigating bone loss with age. However, nutrients do not solely work in isolation, and there is growing evidence that many other nutrients and dietary bioactives play a synergistic role in supporting bone health. Large randomized controlled trials, particularly in traditionally underserved subpopulations (eg, people of color, transgender individuals, older adults, etc), are needed to fully elucidate the effects of diet and exercise on bone health across the lifespan.

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Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial

Cited by 7 publications

References 25 publications

Diet-Induced Rodent Obesity Is Prevented and the Fecal Microbiome Is Improved with Elderberry (Sambucus nigra ssp. canadensis) Juice Powder

Diet-Induced Rodent Obesity Is Prevented and the Fecal Microbiome Is Improved with Elderberry (Sambucus nigra ssp. canadensis) Juice Powder

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

Sorting Dietary Advice for Bone Health

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