Moderate correlation between quality of life and disease activity in adult patients with atopic dermatitis

Haeck, Inge; Berge, Onno ten; Velsen, Sara G.A. van; Bruin‐Weller, Marjolein S. de; Bruijnzeel-Koomen, Carla A.F.M.; Knol, Mirjam J.

doi:10.1111/j.1468-3083.2011.04043.x

Cited by 47 publications

(45 citation statements)

References 40 publications

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“…This study clearly demonstrated the relationship between disease severity and patient quality of life, with the SCORAD index, PO-SCORAD and DLQI scores all having decreased significantly by 55-60% (p < 0.0001) from inclusion. The fact that the SCORAD index was fairly well correlated with the DLQI (r = 0.52, change from baseline) contrasts with the results of two recent studies [14,15], which both showed a poor correlation between the SCORAD index and DLQI.…”

Section: Discussioncontrasting

confidence: 54%

“…This poor correlation can be logically explained by the fact that Van Valburg et al [14] and Haeck et al [15] used the objective SCORAD index, which does not take into account pruritus and sleep loss. Indeed, these 2 subjective symptoms, which are included in the SCORAD index and PO-SCORAD, play a major role in a patient's quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…Specific quality of life scales such as the Dermatology Life Quality Index (DLQI) [11] and Dermatitis Family Questionnaire Impact (DFQI) [12] measure the impact of eczema and its treatment on the quality of life of patients and their family, respectively. Although some studies showed a positive association between SCORAD index and DFQI score [13], other data failed to confirm a correlation between quality of life and clinical AD severity [14,15]. …”

Section: Introductionmentioning

confidence: 99%

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Analysis of Correlations between Patient-Oriented SCORAD (PO-SCORAD) and Other Assessment Scores of Atopic Dermatitis Severity and Quality of Life

Coutanceau

Stalder²

2014

Dermatology

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Objective: Self-assessment scores such as the Patient-Oriented Scoring of Atopic Dermatitis (PO-SCORAD) index being recommended by public health authorities for chronic disease management, we aimed at analysing correlations between PO-SCORAD and physician and patient assessment scores of atopic dermatitis (AD) severity and quality of life. Methods: We perfomed an observational study conducted in 12 European countries in 4,222 atopic patients aged ≥1 month and prescribed Exomega® emollient cream. AD severity was measured by the SCORAD index, PO-SCORAD, Patient-Oriented Eczema Measure (POEM) and Self-Administered Eczema Area and Severity Index (SA-EASI) scales, and patient and family quality of life by the Dermatology Life Quality Index (DLQI) and Dermatitis Family Questionnaire Impact (DFQI) scales, respectively. Their correlations were analysed. Results: PO-SCORAD was the only self-assessment score to be highly correlated with the SCORAD index and POEM (r ≥ 0.70). It was also the best correlated with the DLQI (r = 0.67) and DFQI (r = 0.56). After a 5-week treatment, SCORAD index and PO-SCORAD severity scores had decreased significantly by 60 and 56% (p < 0.0001), and quality of life had improved. Conclusion: PO-SCORAD is better correlated with quality of life scales than other self-assessment scores.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of Correlations between Patient-Oriented SCORAD (PO-SCORAD) and Other Assessment Scores of Atopic Dermatitis Severity and Quality of Life

Coutanceau

Stalder²

2014

Dermatology

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“…3 Reasons for this are unknown. Studies investigating this disconnect may help clinicians and researchers better understand the disease from the patient perspective and develop better outcome measures.…”

Section: Quality Of Lifementioning

confidence: 96%

Research Gaps in Quality of Life and Economic Burden of Atopic Dermatitis

2016

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“…A moderate correlation between HRQoL and disease activity is not a unique finding for CSU patients, but has also been noticed in different (dermatologic and other) conditions. For example, the DLQI score was found to have a relatively poor correlation with disease activity in an Italian population of psoriasis patients as well as in a Dutch population of atopic dermatitis patients [27,28]. Additionally, moderate correlations between disease activity and HRQoL were found in subjects suffering from inflammatory bowel disease [29].…”

Section: Discussionmentioning

confidence: 99%

Disease Activity Only Moderately Correlates with Quality of Life Impairment in Patients with Chronic Spontaneous Urticaria

Koti¹,

Weller²,

Makris³

et al. 2013

Dermatology

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Background: The impact of chronic spontaneous urticaria (CSU) on health-related quality of life (HRQoL) is widely held to be mainly influenced by disease activity and comorbidities. Objective: To assess the correlation between disease activity and HRQoL impairment by using validated disease-specific instruments. Methods: The Chronic Urticaria Quality of Life Questionnaire (CU-Q₂oL) was translated into Greek and subsequently applied to 110 CSU patients along with the Dermatology Life Quality Index and the Urticaria Activity Score. After the validity and reliability of the Greek CU-Q₂oL had been determined, we assessed the relation between disease activity and HRQoL impairment by computing correlations as well as by performing multiple regression analysis. Results: Exploratory factor analysis revealed a six-scale structure of the Greek CU-Q₂oL that explained 67.9% of its total variance. The internal consistency was satisfactory with Cronbach's α >0.7. Disease activity was the only predictor of quality of life impairment, but it only moderately correlated with the CU-Q₂oL total score (r = 0.40, p < 0.0001). Conclusion: Our results suggest that there are additional factors to disease activity that are responsible for the pronounced reduction of HRQoL in CSU, and this supports the recommendation to assess and monitor both disease activity and quality of life in CSU patients.

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Moderate correlation between quality of life and disease activity in adult patients with atopic dermatitis

Cited by 47 publications

References 40 publications

Analysis of Correlations between Patient-Oriented SCORAD (PO-SCORAD) and Other Assessment Scores of Atopic Dermatitis Severity and Quality of Life

Analysis of Correlations between Patient-Oriented SCORAD (PO-SCORAD) and Other Assessment Scores of Atopic Dermatitis Severity and Quality of Life

Research Gaps in Quality of Life and Economic Burden of Atopic Dermatitis

Disease Activity Only Moderately Correlates with Quality of Life Impairment in Patients with Chronic Spontaneous Urticaria

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