Moderate disaccharide malabsorption does not affect weight gain and cecal cell proliferation in piglets

Cl, Kien; Cooper, JR; Frankel, Wendy L.

doi:10.1177/0148607103027005323

J Parenter Enteral Nutr

2003

DOI: 10.1177/0148607103027005323

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Moderate disaccharide malabsorption does not affect weight gain and cecal cell proliferation in piglets

Kien Cl¹,

JR Cooper²,

Wendy L. Frankel³

Abstract: These data suggest that moderate (50%) disaccharide malabsorption per se does not cause diarrhea and does not impair dietary energy use or colonic cell proliferation.

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Cited by 2 publications

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“…Previously, we used graded doses of lactulose, an indigestible disaccharide of fructose and galactose, to study fermentation and cecal cell proliferation and apoptosis in piglets (16)(17)(18). In 2 earlier studies (16,17), chronic feeding of lactulose at large doses sufficient to cause osmotic diarrhea did not affect weight gain or apparent dietary energy utilization but caused abnormally decreased cecal cell proliferation.…”

mentioning

confidence: 99%

Increased Colonic Luminal Synthesis of Butyric Acid Is Associated with Lowered Colonic Cell Proliferation in Piglets ,

Kien

Schmitz-Brown

Solley

et al. 2006

The Journal of Nutrition

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Butyrate inhibits colonic cell proliferation in vitro but reportedly has an opposite effect in vivo. Because lactulose feeding decreases cecal cell proliferation, an effect attenuated by prefeeding inulin, we hypothesized that lactulose feeding would decrease colonic luminal synthesis of butyrate, and that prefeeding and cofeeding inulin would prevent this effect. Piglets (n = 31) were catheterized and randomly assigned to 1 of 4 groups: Control formula (C); control formula + lactulose (L); control formula + lactulose + inulin (L + I); and control formula + inulin (I). At 6 and 7 d postsurgery, the rate of cecal synthesis of butyrate, cecal cell proliferation and apoptosis, and cecal and distal colon butyrate concentration were measured. In groups C, L, L + I, and I, the rates of synthesis of butyrate (mean +/- SEM) were 10.6 +/- 3.2, 23.3 +/- 4.5, 12.4 +/- 3.6, and 14.6 +/- 4.0 micromol/min, respectively (Group Effect, P = 0.1; C vs. L, P = 0.03; L vs. L + I, P = 0.06). The cecal butyrate concentrations did not differ among the 4 groups and were 8.7 +/- 3.2, 2.4 +/- 0.8, 3.4 +/- 1.9, and 2.0 +/- 0.7 micromol/g dry wt, respectively. The total cecal cell proliferation index was higher in C than in L (P = 0.008) or I (P = 0.026) and was higher in L + I than in L (P = 0.013) or I (P = 0.046). The increased supply of butyrate to the cecum was associated with decreased cell proliferation, but cecal butyrate concentration did not reflect synthesis.

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mentioning

confidence: 99%

Increased Colonic Luminal Synthesis of Butyric Acid Is Associated with Lowered Colonic Cell Proliferation in Piglets ,

Kien

Schmitz-Brown

Solley

et al. 2006

The Journal of Nutrition

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The Suckling Piglet as an Agrimedical Model for the Study of Pediatric Nutrition and Metabolism

Odle

Lin

Jacobi

et al. 2014

Annu. Rev. Anim. Biosci.

111

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The neonatal pig ranks among the most prominent research models for the study of pediatric nutrition and metabolism. Its precocial development at birth affords ready adaptation to artificial rearing systems, and research using this model spans a wide array of nutrients. Sophisticated in vitro and in vivo methodologies supporting both invasive, reduction-science research as well as whole-animal preclinical investigations have been developed. Potential applications may dually benefit both agricultural and medical sciences (e.g., "agrimedical research"). The broad scope of this review is to outline the fundamental elements of the piglet model and to highlight key aspects of relevance to various macronutrients, including lipids, carbohydrates, proteins/amino acids, and calcium/phosphorus. The review examines similarities between piglets and infants and also piglet idiosyncrasies, concluding that, overall, the piglet represents an adaptable and robust model for pediatric nutrition and metabolism research.

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Moderate disaccharide malabsorption does not affect weight gain and cecal cell proliferation in piglets

Abstract: These data suggest that moderate (50%) disaccharide malabsorption per se does not cause diarrhea and does not impair dietary energy use or colonic cell proliferation.

Cited by 2 publications

References 17 publications

Increased Colonic Luminal Synthesis of Butyric Acid Is Associated with Lowered Colonic Cell Proliferation in Piglets ,

Increased Colonic Luminal Synthesis of Butyric Acid Is Associated with Lowered Colonic Cell Proliferation in Piglets ,

The Suckling Piglet as an Agrimedical Model for the Study of Pediatric Nutrition and Metabolism

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