Moderate intake of n−3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects

Mabile, Laurence; Piolot, A.; Boulet, Lucie; Fortin, Louis-Jacques; Doyle, Nancy; Rodríguez, Claudia; Davignon, Jean; Blache, Denis; Lussier‐Cacan, Suzanne

doi:10.1093/ajcn/74.4.449

Cited by 50 publications

(32 citation statements)

References 43 publications

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“…In addition, docosahexaenoic acid, one of the n-3 HUFA, affects the fluidity and rigidity of the cell membrane structure [27]. Previous studies have also suggested that stability of erythrocytes is related to the n-3 HUFA content in the biomembrane of erythrocytes [28][29][30]. Digestive absorption of lipid is promoted with bile acid, and bile acid conjugates with glycine and/or taurine prior to secretion [31].…”

Section: Discussionmentioning

confidence: 99%

Role of taurine deficiency in inducing green liver symptom and effect of dietary taurine supplementation in improving growth in juvenile red sea bream Pagrus major fed non-fishmeal diets based on soy protein concentrate

et al. 2011

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This study was conducted to investigate the mechanism of green liver symptom induction and the effect of dietary taurine supplementation on growth performance in juvenile red sea bream fed non-fishmeal diets based on soy protein concentrate (SPC). Juvenile fish (initial BW 72 g) were fed for 20 weeks on SPC diets supplemented with taurine at levels of 0, 1.0, and 2.0%. In the taurineunsupplemented SPC diet group, specific growth rate (SGR) and feed conversion ratio (FCR) were significantly inferior (P \ 0.001), and incidence of green liver was observed in 70% of fish. In this group, hepatopancreatic and plasma taurine concentrations were lowest (P \ 0.05), hepatopancreatic content of bile pigments was highest (P \ 0.05), and osmotic tolerance of erythrocytes was inferior (P \ 0.05) among the dietary treatment groups. Serum osmolality of all treatment groups was at similar levels. These physiological abnormalities as well as SGR and FCR were improved by dietary taurine supplementation. These results indicate that the mechanism for induction of green liver symptom is bile pigment overproduction due to increased hemolysis because erythrocytes become osmotically fragile due to dietary taurine deficiency. Taurine supplementation of SPC diets is essential for maintaining normal physiological condition and growth performance in juvenile red sea bream.

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Section: Discussionmentioning

confidence: 99%

Role of taurine deficiency in inducing green liver symptom and effect of dietary taurine supplementation in improving growth in juvenile red sea bream Pagrus major fed non-fishmeal diets based on soy protein concentrate

et al. 2011

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“…In addition to LDL in vitro oxidation, another measure of overall antioxidant defense based on the susceptibility of erythrocytes to free radical-induced hemolysis has been set up and used under various clinical and experimental conditions (5,22,32).…”

Section: Introduction E Xperimental and Clinical Studies Have Documentedmentioning

confidence: 99%

Effect of Exercise Training onIn VitroLDL Oxidation and Free Radical–Induced Hemolysis: The HERITAGE Family Study

Blache

Lussier‐Cacan

Gagnon

et al. 2007

Antioxidants & Redox Signaling

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Oxidant stress and overproduction of reactive oxygen species (ROS) contribute to the development of cardiovascular disease. Oxidative modifications of low-density lipoproteins (LDL) are thought to play an early and critical role in atherogenesis. LDL oxidation can be reproduced in vitro, but results usually show a large interindividual variation not entirely explained by the environment. Free radical-induced hemolysis is also proposed to reveal the overall antioxidant capacity. The roles of genetic factors and exercise on the variability of both measures were investigated. The study was conducted in 146 healthy individuals from 28 families participating in a 20-week exercise-training program. In addition to important biological and environmental influences on variation, significant familial aggregation was detected in all oxidation measures. Exercise did not significantly modify the LDL oxidation parameters, but significantly increased resistance was observed in the free radical-induced hemolysis, especially in women, this effect was not observed in smokers. In total, the findings suggest the presence of familial effects in the response to ex vivo oxidation. Further, smoking negates the beneficial effect of exercise training on erythrocyte resistance to free radical-induced hemolysis. These observations emphasize the importance of context in the evaluation of exercise and oxidant stress.

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“…Reactive oxygen species (ROS) generated in the plasma, cytosol, or cell membrane can attack erythrocyte membranes, compromise their integrity, and induce the oxidation of lipids and protein resulting in hemolysis (Bracci et al 2002, Chan et al 1999, Delmas-Beauvieux et al 1995, Niki et al 1988. Given their function, and their susceptibility to oxidative damage, investigators have used erythrocytes, and free radical initiators such as 2,2 0 -azo-bis (2-amidinopropane) dihydrochloride (AAPH) and UVB as models for studying biomembrane oxidative damage (Carini et al 2000, Chan et al 1999, Liu et al 2002, Mabile et al 2001, Niki et al 1988, Zhu et al 2002. We recently studied the inhibitory effects of flavanoid-rich cocoa extract on rat erythrocyte hemolysis, and found that hemolysis resistance was enhanced following the feeding of this extract ðp , 0:05Þ (Zhu et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Influence of Cocoa Flavanols and Procyanidins on Free Radical‐induced Human Erythrocyte Hemolysis

Zhu

Schramm

Gross

et al. 2005

Journal of Immunology Research

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Cocoa can be a rich source of antioxidants including the flavan-3-ols, epicatechin and catechin, and their oligomers (procyanidins). While these flavonoids have been reported to reduce the rate of free radical-induced erythrocyte hemolysis in experimental animal models, little is known about their effect on human erythrocyte hemolysis. The major objective of this work was to study the effect of a flavonoid-rich cocoa beverage on the resistance of human erythrocytes to oxidative stress. A second objective was to assess the effects of select purified cocoa flavonoids, epicatechin, catechin, the procyanidin Dimer B2 and one of its major metabolites, 3 0 -O-methyl epicatechin, on free radical-induced erythrocyte hemolysis in vitro. Peripheral blood was obtained from 8 healthy subjects before and 1, 2, 4 and 8 h after consuming a flavonoid-rich cocoa beverage that provided 0.25 g/kg body weight (BW), 0.375 or 0.50 g/kg BW of cocoa. Plasma flavanol and dimer concentrations were determined for each subject. Erythrocyte hemolysis was evaluated using a controlled peroxidation reaction. Epicatechin, catechin, 3 0 -O-methyl epicatechin and (-)-epicatechin-(4b . 8)-epicatechin (Dimer B2) were detected in the plasma within 1 h after the consumption of the beverage. The susceptibility of erythrocytes to hemolysis was reduced significantly following the consumption of the beverages. The duration of the lag time, which reflects the capacity of cells to buffer free radicals, was increased. Consistent with the above, the purified flavonoids, epicatechin, catechin, Dimer B2 and the metabolite 3 0 -O-methyl epicatechin, exhibited dose-dependent protection against AAPH-induced erythrocyte hemolysis at concentrations ranging from 2.5 to 20 mM. Erythrocytes from subjects consuming flavonoid-rich cocoa show reduced susceptibility to free radical-induced hemolysis ðp , 0:05Þ.

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Moderate intake of n−3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects

Abstract: Although they exhibit a high susceptibility to oxidation, n-3 fatty acids may preserve membrane integrity and represent an added benefit in the treatment of hypertriglyceridemic patients.

Cited by 50 publications

References 43 publications

Role of taurine deficiency in inducing green liver symptom and effect of dietary taurine supplementation in improving growth in juvenile red sea bream Pagrus major fed non-fishmeal diets based on soy protein concentrate

Role of taurine deficiency in inducing green liver symptom and effect of dietary taurine supplementation in improving growth in juvenile red sea bream Pagrus major fed non-fishmeal diets based on soy protein concentrate

Effect of Exercise Training onIn VitroLDL Oxidation and Free Radical–Induced Hemolysis: The HERITAGE Family Study

Influence of Cocoa Flavanols and Procyanidins on Free Radical‐induced Human Erythrocyte Hemolysis

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