Moderate Intensity Endurance and Resistance Exercise Attenuates Cachexia in Tumor-bearing Mice

Wood, Nicole; Garritson, Jacob; Mathias, Alissa; Haughian, James M.; Hayward, Reid

doi:10.21873/anticanres.15498

Cited by 4 publications

(4 citation statements)

References 45 publications

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“…For example, one study has demonstrated that combined RT and ET can increase muscle mass and strength while regulating autophagy and proteasome-mediated degradation [162]. Another study has shown that combined RT and ET can mitigate the reduction in muscle mass in C26-induced cancer cachexia by reducing systemic inflammation [163]. These pre-clinical studies on animal models suggest potential benefits to combat CC, including increased protein synthesis and improved muscle wasting from both RT and ET.…”

Section: Exercise In Managing Cancer Cachexiamentioning

confidence: 99%

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Pradhan,

Dieterich,

Natarajan

et al. 2024

Cancers

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Cancer cachexia is a multifaceted syndrome that impacts individuals with advanced cancer. It causes numerous pathological changes in cancer patients, such as inflammation and metabolic dysfunction, which further diminish their quality of life. Unfortunately, cancer cachexia also increases the risk of mortality in affected individuals, making it an important area of focus for cancer research and treatment. Several potential nutritional therapies are being tested in preclinical and clinical models for their efficacy in improving muscle metabolism in cancer patients. Despite promising results, no special nutritional therapies have yet been validated in clinical practice. Multiple studies provide evidence of the benefits of increasing muscle protein synthesis through an increased intake of amino acids or protein. There is also increasing evidence that exercise can reduce muscle atrophy by modulating protein synthesis. Therefore, the combination of protein intake and exercise may be more effective in improving cancer cachexia. This review provides an overview of the preclinical and clinical approaches for the use of amino acids with and without exercise therapy to improve muscle metabolism in cachexia.

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Section: Exercise In Managing Cancer Cachexiamentioning

confidence: 99%

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Pradhan,

Dieterich,

Natarajan

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…Loss of muscle mass causes fatigue and creates a vicious cycle of reduced activity and further muscle atrophy. Moreover, anabolic stimulation by muscle contraction is required to maintain the body's protein at acceptable levels (55,56). Thus, it is important for clinicians to recommend light exercises, such as walking, to prevent loss of muscle mass (50,51).…”

Section: Non-pharmaceutical Therapies For Cancer Cachexiamentioning

confidence: 99%

The Latest Treatments for Cancer Cachexia: An Overview

Watanabe

Oshima

2023

Anticancer Res

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“…This may be achieved through mechanisms such as autophagy modulation and enhanced mitochondrial function, as evidenced in animal models [ 282 ]. Indeed, Wood et al, demonstrated that the combination of aerobic exercise and resistance exercise training can lead to significant reductions in systemic inflammation as indicated by lower spleen mass and plasma IL-6 levels in BALB/c mice [ 306 ]. In human cancer patients, a combination exercise protocol enhanced type II muscle fibers and the strength of the knee and elbow muscles while regulating the markers related to autophagy, the UPS system (FOXO3, MuRF1, Atrogin-1), and protein synthesis (mTOR, 3EBP1, S6rp) during chemotherapy and cancer cachexia [ 307 ].…”

Section: Potential Therapeutic Interventions For Cancer Cachexiamentioning

confidence: 99%

Cancer Cachexia: Underlying Mechanisms and Potential Therapeutic Interventions

Directo,

Lee

2023

Metabolites

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Cancer cachexia, a multifactorial metabolic syndrome developed during malignant tumor growth, is characterized by an accelerated loss of body weight accompanied by the depletion of skeletal muscle mass. This debilitating condition is associated with muscle degradation, impaired immune function, reduced functional capacity, compromised quality of life, and diminished survival in cancer patients. Despite the lack of the known capability of fully reversing or ameliorating this condition, ongoing research is shedding light on promising preclinical approaches that target the disrupted mechanisms in the pathophysiology of cancer cachexia. This comprehensive review delves into critical aspects of cancer cachexia, including its underlying pathophysiological mechanisms, preclinical models for studying the progression of cancer cachexia, methods for clinical assessment, relevant biomarkers, and potential therapeutic strategies. These discussions collectively aim to contribute to the evolving foundation for effective, multifaceted counteractive strategies against this challenging condition.

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Moderate Intensity Endurance and Resistance Exercise Attenuates Cachexia in Tumor-bearing Mice

Cited by 4 publications

References 45 publications

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

The Latest Treatments for Cancer Cachexia: An Overview

Cancer Cachexia: Underlying Mechanisms and Potential Therapeutic Interventions

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