“…In this context, regular physical activity has been associated with several beneficial effects in SCD mice, especially regarding energetics in exercising muscle (particularly, reducing acidosis; Chatel et al, 2018a), inflammation (Charrin et al, 2017), haemorheological characteristics (Aufradet et al, 2014;Faes, Charrin, Connes, Pialoux, & Martin, 2015) and oxidative stress Chatel et al, 2018a). These beneficial effects have been confirmed by the lower spleen weight and congestion reported in SCD mice submitted to training in comparison to their sedentary counterparts (Charrin et al, 2017;Chatel et al, 2018a) and in a very recent study conducted in patients in whom moderate-intensity endurance-exercise training seemed to be safe and improved the functional capacity of adults with SCD (Gellen et al, 2018). Given that oxidative stress (Charles et al, 2017;Lejay et al, 2014) and acidosis (Jubrias, Crowther, Shankland, Gronka, & Conley, 2003) largely impact mitochondrial respiration, it might be hypothesized that endurance training could also reduce the I/R-induced mitochondrial dysfunction we previously reported in SCD mice (Chatel et al, 2018c).…”