Moderate Mocha Coffee Consumption Is Associated with Higher Cognitive and Mood Status in a Non-Demented Elderly Population with Subcortical Ischemic Vascular Disease

Fisicaro, Francesco; Lanza, Giuseppe; Pennisi, Manuela; Vagli, Carla; Cantone, Mariagiovanna; Pennisi, Giovanni; Ferri, Raffaele; Bella, Rita

doi:10.3390/nu13020536

Cited by 29 publications

(15 citation statements)

References 89 publications

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“…Researchers discovered a significant difference in age and education among the four groups of subjects based on their daily mocha coffee consumption. However, the General Regression Model revealed that the associations between coffee consumption and cognition and mood were independent of socio-demographic variables ( Fisicaro et al, 2021 ). In terms of the sex-related effect, an earlier prospective study ( Shinoda et al, 2015 ) of 455 participants (314 men) found that male drinkers had a lower incidence of small vessel disease than male non-drinkers and occasional drinkers, while female drinkers had a lower incidence of white matter lesions (WMLs) than female non-drinkers or occasional drinkers.…”

Section: Sex-specific Differences In Vadmentioning

confidence: 99%

Vascular Dementia and Underlying Sex Differences

Akhter

Persaud

Zaokari

et al. 2021

Front. Aging Neurosci.

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Vascular dementia (VaD) is the second most common form of dementia after Alzheimer’s disease (AD); where Alzheimer’s accounts for 60–70% of cases of dementia and VaD accounts for 20% of all dementia cases. VaD is defined as a reduced or lack of blood flow to the brain that causes dementia. VaD is also known occasionally as vascular contributions to cognitive impairment and dementia (VCID) or multi-infarct dementia (MID). VCID is the condition arising from stroke and other vascular brain injuries that cause significant changes to memory, thinking, and behavior, and VaD is the most severe stage while MID is produced by the synergistic effects caused by multiple mini strokes in the brain irrespective of specific location or volume. There are also subtle differences in the presentation of VaD in males and females, but they are often overlooked. Since 1672 when the first case of VaD was reported until now, sex and gender differences have had little to no research done when it comes to the umbrella term of dementia in general. This review summarizes the fundamentals of VaD followed by a focus on the differences between sex and gender when an individual is diagnosed. In addition, we provide critical evidence concerning sex and gender differences with a few of the main risk factors of VaD including pre-existing health conditions and family history, gene variants, aging, hormone fluctuations, and environmental risk factors. Additionally, the pharmaceutical treatments and possible mitigation of risk factors is explored.

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Section: Sex-specific Differences In Vadmentioning

confidence: 99%

Vascular Dementia and Underlying Sex Differences

Akhter

Persaud

Zaokari

et al. 2021

Front. Aging Neurosci.

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“…Fourthly, the lack of a group of patients with H-type hypertension but no SIVD prevented a deeper analysis of the effects of gender differences. Finally, in addition to the risk factor for SIVD and the role of H-type hypertension, future study may also consider the effect of protective factors in this population, such as the role of caffeine or acetyl-L-carnitine intake on mood and cognition ( Pennisi et al, 2020 ; Fisicaro et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Gender difference in association between H-type hypertension and subcortical ischemic vascular disease

Wang

Xi²,

Li³

et al. 2022

Front. Aging Neurosci.

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BackgroundSubcortical ischemic vascular disease (SIVD) is a leading cause of vascular dementia. The present study tries to explore not only the gender-specific association between H-type hypertension and SIVD but also the indirect effects of H-type hypertension on cognition through the ischemic brain injury caused by SIVD.Materials and methodsA total of 601 SIVD patients were included, comprising 322 males and 279 females. H-type hypertension was defined as hypertension accompanied with elevated serum total homocysteine (tHcy) level. The imaging manifestations of ischemic brain injury caused by SIVD were also evaluated, including white matter lesions (WML), lacunar infarction (LI) and brain atrophy (BA). Gender-specific subgroup analyses in association between H-type hypertension and SIVD were conducted, followed by a structural equation model based evaluation of the gender-specific mediating effects of SIVD on the relationship between H-type hypertension and cognition.ResultsFor males, there was no noticeable difference in WML, LI and BA scores among control group, isolated hypertension group, isolated high tHcy group, and H-type hypertension group in most brain regions, but significant difference was found in all brain regions for females. Multiple regression analyses showed that H-type hypertension was significantly associated with WML, LI and BA for females, but not for males. For males, H-type hypertension mainly affected cognition through direct effect, while the H-type hypertension effect was mediated by ischemic brain injury caused by SIVD for females.ConclusionH-type hypertension was more closely related to SIVD for females than males, suggesting a gender-specific difference in association patterns between H-type hypertension and cognition.

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“…First, interventions that slow the hallmarks of aging will decrease the risk of both groups of diseases. It has been consistently shown that a healthy lifestyle and metabolism can decrease the risk of both cancer and cognitive decline [ 61 , 62 , 63 , 64 , 65 , 66 ]. In addition, related interventions are known to decrease markers of inflammation, improve mitochondrial health and decrease oxidative stress [ 67 , 68 ].…”

Section: Introductionmentioning

confidence: 99%

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

Salemi

Mogavero

Lanza

et al. 2022

Cells

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Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia is the most common, while Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease—even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.

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Moderate Mocha Coffee Consumption Is Associated with Higher Cognitive and Mood Status in a Non-Demented Elderly Population with Subcortical Ischemic Vascular Disease

Cited by 29 publications

References 89 publications

Vascular Dementia and Underlying Sex Differences

Vascular Dementia and Underlying Sex Differences

Gender difference in association between H-type hypertension and subcortical ischemic vascular disease

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

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