Moderate prenatal alcohol exposure increases total length of L1-expressing axons in E15.5 mice

Abstract

Figure 1 Moderate prenatal alcohol exposure increases total length of L1+ axons, but has no impact on body weight in E15.5 mice. (a) Representative pictures of E15.5 coronal brain sections of alcohol-and saline-exposed groups. Atlas levels are in reference to an E16 mouse brain atlas (Schambra, 2008) in coronal sections. (b) There is no effect of sex (p = 0.46) or treatment (p = 0.17) on embryonic body weight nor is there an interaction between sex or treatment ( p = 0.895, Two-way ANOVA; alcohol males: n = 7, 0.38 ± 0.06g, alcohol females: n = 5, 0.36 ± 0.08g, saline males: n = 10, 0.34 ± 0.095g, saline females: n = 8, 0.32 ± 0.04g). (c) Rostral and middle caudal sections showed a significant increase in total length of L1+ axons in the alcohol group compared to the saline group (rostral, alcohol group:

Формирование Нейрональных Элементов Нейроиммунной Системы Эмбрионального Мозга Человека При Пренатальном Влиянии Алкоголя

“…Активация глии -это проявление компенсаторной реакции, вызванной нейропластическими изменениями и направленной на адаптацию развивающегося мозга эмбриона и плода в условиях нейротоксичности и гипоксии под действием этанола. Микроглия является фундаментальной основой для формирования нормальных процессов в ЦНС, включая нейрогенез [13,14], а также образования, роста и функционирования нейронных элементов, таких как синапсы и рецепторы [21,22,23]…”

“…Siberian Herald of Psychiatry and Addiction Psychiatry. 2023; 1 (118): 14-22. https://doi.org/10.26617/1810-3111-2023-1(118)- [14][15][16][17][18][19][20][21][22] Formation of neuronal elements of the neuroimmune system of the human embryonic brain under the prenatal influence of alcohol Shushpanova T.V. 1 , Solonsky A.V.…”

Prenatal alcohol exposure alters axon formation and Robo/Slit guidance cue expression in the internal capsule at E15.5

“…L1 is a neural cell adhesion molecule expressed on all three axon tracts. We previously showed that L1-positive axons were longer at this age in PAE mice 3 , thus we wanted to investigate if PAE changed the number of axons crossing this checkpoint. Analysis revealed a significant Treatment X Sex interaction (t57 = 2.78, p = 0.007, Figure).…”