Moderate temperature reduction is sufficient for prevention of 5-fluorouracil-induced oral mucositis: an experimental in vivo study in rats

Walladbegi, Java; Dankis, Martin; Aydoğdu, Özgü; Jontell, Mats; Winder, Michael

doi:10.1007/s00280-022-04495-3

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Further, moderate temperature reduction was su cient to reduce the early events which may precede clinically established OM. This could have clinical advantages in terms of tolerability [29].…”

Section: Discussionmentioning

confidence: 99%

Cryopreventive temperatures prior to chemotherapy

Ibrahim

Camci

Khairallah

et al. 2023

Preprint

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Background: The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings, cooling is usually initiated prior to the chemotherapy infusion. It then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug, there is no consensus on when cooling should be initiated prior to the infusion. The lowest achieved temperature in the oral mucosa is believed to provide the best conditions to prevent OM. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature is achieved. Subjects and method: In total, 20 healthy volunteers participated in this randomized crossover trial. Each subject attended three separate cooling sessions of 30 minutes each, with ice chips (IC) and the intraoral cooling device (ICD) set to 8°C and 15°C, respectively. At baseline and following 5, 10, 15, 20 and 30 minutes of cooling, intraoral temperatures were registered using a thermographic camera. Results: The greatest drop in intraoral temperature was seen after 5 minutes of cooling with both IC, ICD8°C and ICD15°C, respectively. A statistically significant difference, corresponding to 1.4°C was seen between IC and the ICD15°C (p < 0.05). The intraoral temperature further declined throughout the 30 minutes of cooling, showing an additional temperature reduction of 3.1°C, 2.2°C, and 1.7°C for IC, ICD8°C and ICD15°C, respectively. Conclusion: The greatest drop in intraoral temperature is seen following 5 minutes of cooling.

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Section: Discussionmentioning

confidence: 99%

Cryopreventive temperatures prior to chemotherapy

Ibrahim

Camci

Khairallah

et al. 2023

Preprint

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“…Further, moderate temperature reduction was sufficient to reduce the early events which may precede clinically established OM. This could have clinical advantages in terms of tolerability [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Cryopreventive temperatures prior to chemotherapy

et al. 2023

Self Cite

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The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings, cooling is usually initiated prior to the chemotherapy infusion. It then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug, there is no consensus on when cooling should be initiated prior to the infusion. The lowest achieved temperature in the oral mucosa is believed to provide the best condition for OM prevention. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature is achieved. In total, 20 healthy volunteers participated in this randomized crossover trial. Each subject attended three separate cooling sessions of 30 min each, with ice chips (IC) and the intraoral cooling device (ICD) set to 8 and 15 °C, respectively. At baseline and following 5, 10, 15, 20 and 30 min of cooling, intraoral temperatures were registered using a thermographic camera. The greatest drop in intraoral temperature was seen after 5 min of cooling with IC, ICD8°C and ICD15°C, respectively. A statistically significant difference, corresponding to 1.4 °C, was seen between IC and the ICD15°C (p < 0.05). The intraoral temperature further declined throughout the 30 min of cooling, showing an additional temperature reduction of 3.1, 2.2, and 1.7 °C for IC, ICD8°C and ICD15°C, respectively.

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“…This as the former resulted in a temperature reduction of 7.9 °C after 60 min of cooling [ 13 ], compared to 2.3 °C, and 3.7 °C in the present study for the intraoral mucosa as a whole and the non-keratinized areas, respectively. Although the differences in mean temperature reduction seems striking, in a recent in vivo study in rats [ 22 ] it was demonstrated that cooling to low temperatures (< 30 °C), which causes discomfort for the patient, may not be necessary to prevent OM. However, this is yet to be assessed in a clinical setting.…”

Section: Discussionmentioning

confidence: 99%

An extraoral approach to intraoral cooling–a feasibility study in non-cancer patients

Najaf,

Borgvall,

Vennman

et al. 2023

BMC Oral Health

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Background Cryotherapy, using ice chips (IC) is an effective strategy to prevent chemotherapy-induced oral mucositis (OM) in selected cancer patient cohorts. However, although effective, use of IC may cause adverse reactions, e.g., nausea, numbness, and shooting pain in the teeth, which could have an adverse impact on the medical treatment. Furthermore, IC requires water of good quality to minimize risk of serious systemic infections. To eliminate these disadvantages, novel cooling devices have emerged as alternative cooling modalities. Thus, the aim was to evaluate the efficacy and tolerability profile of extraoral cooling for intraoral temperature reduction. Subjects and Methods This experimental pilot study was conducted at the Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. In total, six healthy volunteers were enrolled in this study. At baseline and following 30-, and 60 min of cooling with the extraoral cooling device, intraoral mucosal temperatures were measured using a thermographic camera, and a questionnaire related to tolerability was completed. Results Following 30-, and 60 min of cooling, the intraoral temperature decreased with 2.0 °C and 2.3 °C, respectively. Extraoral cooling was well tolerated, and all subjects endured the entire cooling session of 60 min. Conclusion Extraoral cooling reduces intraoral mucosal temperatures and is a well-tolerated cooling modality.

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Moderate temperature reduction is sufficient for prevention of 5-fluorouracil-induced oral mucositis: an experimental in vivo study in rats

Cited by 3 publications

References 29 publications

Cryopreventive temperatures prior to chemotherapy

Cryopreventive temperatures prior to chemotherapy

Cryopreventive temperatures prior to chemotherapy

An extraoral approach to intraoral cooling–a feasibility study in non-cancer patients

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