Moderate zinc deficiency negatively affects biomechanical properties of rat tibiae independently of body composition☆

Scrimgeour, Angus G.; Stahl, Chad H.; McClung, James P.; Marchitelli, Louis J.; Young, Andrew

doi:10.1016/j.jnutbio.2006.12.018

Cited by 43 publications

(34 citation statements)

References 47 publications

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“…In the present study, BMD was reduced in spine but not in the long bones where consolidation is less during the final stages of peak bone mass due to a higher ratio of cortical bone to trabecular bone [29] . However, in 3-to 5-week-old rats fed a severely zinc-deficient diet, femur BMD was 20% lower after 3 weeks [4] and wholebody BMD was 6% lower after 6 weeks [6] , but BMD in the spine and tibia were not measured in those studies. Scrimgeour et al [6] also reported that young severely zinc-deficient rats had weaker tibias but not femurs based on biomechanical strength testing, and this may be explained by the higher ratio of cortical to trabecular bone in femur versus tibia [31] .…”

Section: Discussionmentioning

confidence: 82%

“…Previous research has investigated the effects of zinc deficiency on bone in the growing rat [4][5][6][26][27][28] ; however, this is the first study to examine bone parameters in 19-week-old young adult rats after consuming zinc-deficient diets for 9 weeks. A novel finding was that BMD was 14% lower in the spine of 9ZD (fed 1-mg Zn/kg diet), but BMD was not altered in the whole body, tibia or femur, or in any of the aforementioned sites in 9MZD rats (fed 5 mg Zn/kg diet), compared to zinc-adequate controls.…”

Section: Discussionmentioning

confidence: 99%

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Zinc Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A Pilot Study

Ryz

Weiler²,

Taylor³

2009

Ann Nutr Metab

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The objective of this study was to investigate the effects of zinc deficiency initiated during adolescence on skeletal densitometry, serum markers of bone metabolism, femur minerals and morphometry in young adult rats. Ten-week-old male rats were fed a <1-mg Zn/kg diet (9ZD), a 5-mg Zn/kg diet (9MZD) or a 30-mg Zn/kg diet (9CTL) for up to 9 weeks. Analyses included bone mineral density, serum osteocalcin and C-terminal peptides of type I collagen, serum zinc, femur zinc, calcium and phosphorus, and femur morphometry. Bone mineral density was 14% lower in the spine of 9ZD, but was not altered in the whole body, tibia or femur, or in any of the aforementioned sites in 9MZD, compared to 9CTL. When adjusted for size, spine bone mineral apparent density was still 8% lower in 9ZD than 9CTL. Serum osteocalcin, a marker for bone formation, was approximately 33% lower in 9ZD compared to both 9MZD and 9CTL. The 9ZD and 9MZD had 57% lower femur zinc and 56–88% lower serum zinc concentrations compared to 9CTL. These findings indicate that severe zinc deficiency initiated during adolescence may have important implications for future bone health, especially with regards to bone consolidation in the spine.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Zinc Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A Pilot Study

Ryz

Weiler²,

Taylor³

2009

Ann Nutr Metab

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show abstract

“…Zinc excess or deficiency can cause body weight loss, including bone mass and density, which may result in bone deformities, low bone mineralization, reduced bone and serum Ca levels (Rath et al, 2000). Although severe zinc deficiency is uncommon in avian populations, marginal deficiency is likely to be much more prevalent, and associated with to immune dysfunctions or restricted physical development (Scrimgeour et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Level and Source (Zinc Oxide Vs. Zinc Glycine) on Bone Mechanical and Geometric Parameters, and Histomorphology in Male Ross 308 Broiler Chicken

Tomaszewska

Muszyński

Dobrowolski

et al. 2017

Rev. Bras. Cienc. Avic.

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The aim of this study was to evaluate the effect of adding zinc (Zn) mineral supplements from organic (ZnGly) and inorganic (ZnO) sources to growing male Ross 308 chickens on the mechanical, geometric, and histomorphometrical parameters of long bones. A corn-soybean meal basal diet was supplemented with Zn at 50 or 100 mg·kg -1 of a premix, except the control group (0 suppl). The serum concentration of insulin-like growth factor 1 was higher in the ZnGly50 group compared with the control group. Positive influence of Zn on the femur is highlighted when considering the significant increase in parameters such as mean relative wall thickness, and maximum elastic and ultimate strengths after Zn administration. Zinc supplementation did not affect tibial parameters. The histomorphometric analysis showed a positive impact of Zn supplementation (irrespective of source and level) on femoral trabecular thickness. Rapid loss in actual bone volume in tibial metaphyseal trabeculae was observed with ZnGly at 50 mg·kg -1 . In conclusion, this study showed that dietary Zn supplementation positively influences bone mechanical properties, confirming its beneficial effect on the development of the skeletal system and bone tissue of broilers tested for a nutritional-osteoporotic factor. Adverse health effects in trabecular bone as a result of the use of Zn at 50 mg·kg -1 of the premix show that supplementing Zn at the recommended dose (100 mg·kg -1 ) is essential.

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“…Although considerable information is available on the role of Zn in the brain (21,22), liver (23,24), immune system (17), and bones (25,26), very few studies have focused on its role in the lungs. In addition to our recent reports on alcohol-induced dampening of GM-CSFR expression and signaling in the alveolar macrophage (16), we have investigated the potential role of Zn deficiency within the alveolar space as a contributing factor, and shown an immunostimulatory role of Zn in the alveolar space in our rat model of chronic alcohol ingestion (unpublished data).…”

mentioning

confidence: 99%

HIV-1–Transgene Expression in Rats Decreases Alveolar Macrophage Zinc Levels and Phagocytosis

Joshi

Raynor

Fan

et al. 2008

Am J Respir Cell Mol Biol

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Moderate zinc deficiency negatively affects biomechanical properties of rat tibiae independently of body composition☆

Cited by 43 publications

References 47 publications

Zinc Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A Pilot Study

Zinc Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A Pilot Study

Effect of Zinc Level and Source (Zinc Oxide Vs. Zinc Glycine) on Bone Mechanical and Geometric Parameters, and Histomorphology in Male Ross 308 Broiler Chicken

HIV-1–Transgene Expression in Rats Decreases Alveolar Macrophage Zinc Levels and Phagocytosis

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