Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya

Ranhotra, Harmit S.; Sharma, Ramesh

doi:10.1007/s12291-010-0011-4

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…The loss of bone mass and/or decrease in bone density is the main manifestation of osteoporosis. As expected, several studies based on large sample sizes have found that highlanders have a higher risk of osteoporosis ( 6 ) and are more likely to suffer hip fractures ( 7 – 9 ). The above research results may be related to the mechanism that high altitude-induced hypoxia may stimulate the secretion of many hormones that have affected bone mineral metabolisms ( 3 , 10 ).…”

Section: Introductionsupporting

confidence: 69%

Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study

Liu

Wang

et al. 2022

Front. Endocrinol.

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IntroductionMusculoskeletal system gradually degenerates with aging, and a hypoxia environment at a high altitude may accelerate this process. However, the comprehensive effects of high-altitude environments on bones and muscles remain unclear. This study aims to compare the differences in bones and muscles at different altitudes, and to explore the mechanism and influencing factors of the high-altitude environment on the skeletal muscle system.MethodsThis is a prospective, multicenter, cohort study, which will recruit a total of 4000 participants over 50 years from 12 research centers with different altitudes (50m~3500m). The study will consist of a baseline assessment and a 5-year follow-up. Participants will undergo assessments of demographic information, anthropomorphic measures, self-reported questionnaires, handgrip muscle strength assessment (HGS), short physical performance battery (SPPB), blood sample analysis, and imaging assessments (QCT and/or DXA, US) within a time frame of 3 days after inclusion. A 5-year follow-up will be conducted to evaluate the changes in muscle size, density, and fat infiltration in different muscles; the muscle function impairment; the decrease in BMD; and the osteoporotic fracture incidence. Statistical analyses will be used to compare the research results between different altitudes. Multiple linear, logistic regression and classification tree analyses will be conducted to calculate the effects of various factors (e.g., altitude, age, and physical activity) on the skeletal muscle system in a high-altitude environment. Finally, a provisional cut-off point for the diagnosis of sarcopenia in adults at different altitudes will be calculated.Ethics and disseminationThe study has been approved by the institutional research ethics committee of each study center (main center number: KHLL2021-KY056). Results will be disseminated through scientific conferences and peer-reviewed publications, as well as meetings with stakeholders.Clinical Trial registration numberhttp://www.chictr.org.cn/index.aspx, identifier ChiCTR2100052153.

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Section: Introductionsupporting

confidence: 69%

Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study

Liu

Wang

et al. 2022

Front. Endocrinol.

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“…The previous studies reveal that when lowlander ascends to high altitude, there is an increase in the lipid profile parameters such as cholesterol, triglycerides, and HDL. [ 6 - 8 ] Studies also indicating that yogic practices performed at high altitude facilitates improvement in health as compared to other exercise forms and has positive effect on biochemical parameters. [ 20 , 24 ] After yogic breathing, similar results are being reflected in our study, all the lipid profile parameters are showing that a significant decline except HDL is increased with non-significant effect.…”

Section: Discussionmentioning

confidence: 99%

“…[2,3] e research also proves that when lowlanders move to high altitude metal instability increases, leading to increase in depression, anxiety also revealing high level of lipid profile having higher level of cholesterol, triglycerides, and low-density lipoprotein (LDL). [4][5][6][7][8] Studies also demonstrate at lipid profile and stress, have strong correlation individuals with high stress levels, and have higher cholesterol, triglycerides, and LDL. [9,10] It has been recognized that there is a change in the psychological mood, behavior, personality, cognitive functioning, and sleeping patron as ascend to high altitude.…”

Section: Introductionmentioning

confidence: 97%

Physical and mental health at high altitude of individuals doing yogic practices

Gupta

Pradhan

Bhanushali

et al. 2022

JNRP

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Objectives: There is an increase trend in the past few years, in the number of people traveling to high altitude for recreational activities such as pilgrims, mountaineering, and climbing and for occupational purposes such as defense and mining which have resulted in increasing in hypoxia conditions and anxiety-related medical problems at high altitude. As it is known that mental stress affects brain and heart functions, a recent research performed on Sudarshan Kriya Yoga (SKY) further validated the effectiveness of SKY on participants (practicing SKY) as compared to control after quantifying mental stress. To study the physiological effect of SKY advance breathing technique when immediately ascends to high altitude, we wanted to study the level of stress and mental well-being of lowlanders at high altitude. Materials and Methods: It is an interventional study performed at high altitudes, with low landers as participants where their biochemical and psychological parameters are being assessed. Results: The result for biochemical parameter cholesterol, triglycerides, low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), very low-density lipoproteins, LDL-HDL ratio, and cholesterol-HDL ratio showed a significant decrease in the pre- and post-analyses values with P ≤ 0.001. Acute mountain sickness (AMS), Warwick-Edinburgh Mental Well-being Scale, and State and Trait Anxiety Inventory (STAI) also show a decreasing trend with significant result in AMS, mental well-being, and non-significant in STAI p value is P = 0.016, P = 0.055, and P = 0.125, respectively. Conclusion: We observed positive outcome both in for biochemical and stress-related parameters with SKY advance program practitioners who have rapidly ascend to high altitude.

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“…However, the study of the influence of altitude on the lipid profile parameters has not been able to show causality due to the wide variability in the available data. A study by Ranhotra and Sharma, when comparing two populations of indigenous Khasis adults living at high and low altitudes, showed a decrease in total cholesterol and LDL of high-altitude residents, accompanied by a decrease in triglyceride levels at high altitudes (Ranhotra and Sharma, 2010 ). Similarly, a study by Siqués et al carried out in natives of low altitudes who were exposed for 8 months at a height of 3,550 m did not reveal changes in total cholesterol levels and was accompanied by an increase in the concentration of triglycerides after altitude exposure (Siqués et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Hematological Parameters, Lipid Profile, and Cardiovascular Risk Analysis Among Genotype-Controlled Indigenous Kiwcha Men and Women Living at Low and High Altitudes

et al. 2021

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Introduction: Human adaptation to high altitude is due to characteristic adjustments at every physiological level. Differences in lipid profile and cardiovascular risk factors in altitude dwellers have been previously explored. Nevertheless, there are no reports available on genotype-controlled matches among different altitude-adapted indigenous populations.Objective: To explore the possible differences in plasma lipid profile and cardiovascular risk among autochthonous Kiwcha people inhabitants of low and high-altitude locations.Methodology: A cross-sectional analysis of plasmatic lipid profiles and cardiovascular risk factors in lowland Kiwchas from Limoncocha (230 m) and high-altitude Kiwchas from Oyacachi (3,800 m).Results: In the low altitude group, 66% were women (n = 78) and 34% (n = 40) were men, whereas in the high altitude group, 59% (n = 56) were women and 41% (n = 41%) were men. We found the proportion of overweight and obese individuals to be higher among low altitude dwellers (p < 0.05). Red blood cells (RBCs), hemoglobin concentration, and SpO2% were higher among high altitude dwellers and the erythrocyte size was found to be smaller at high altitude. The group located at low altitude also showed lower levels of plasma cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), but most of these differences are not influenced by gender or elevation.Conclusions: Living at an altitude elicits well-known adaptive physiological changes such as erythrocyte count, hemoglobin concentration, hematocrit level, and serum glucose level. We also report clinical differences in the plasma lipid profile, with higher levels of cholesterol, HDL, and LDL in inhabitants of the Andes Mountain vs. their Amazonian basin peers. Despite this, we did not find significant differences in cardiovascular risk.

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Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya

Abstract: ABSTRACT

Cited by 9 publications

References 20 publications

Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study

Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study

Physical and mental health at high altitude of individuals doing yogic practices

Hematological Parameters, Lipid Profile, and Cardiovascular Risk Analysis Among Genotype-Controlled Indigenous Kiwcha Men and Women Living at Low and High Altitudes

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