Moderately high doses of the artificial sweetener saccharin potentially induce sleep disorders in mice

Oishi, Katsutaka; Higo-Yamamoto, Sayaka; Yasumoto, Yuki

doi:10.1016/j.nut.2016.03.013

Cited by 13 publications

(9 citation statements)

References 6 publications

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“…In fact, the role of commonly used artificial sweeteners on circadian rhythms is not well established as we are aware of only one report that indicates saccharin disrupts circadian sleep-wake cycle and decreases activity in mice [12]. Here, we clearly demonstrate that Reb-A does not alter circadian rhythmicity.…”

Section: Discussionmentioning

confidence: 50%

“…Therefore, consuming artificial sweetened drinks might help reduce an individual’s caloric intake and promote weight loss. Although this seems like a plausible intervention, evidence indicates that consuming artificial sweeteners might actually decrease physical activity [12], promote obesity [9], and, at least for saccharin, cause insulin resistance [10]. Because obesity and insulin resistance are associated with circadian disruption [11], artificial sweeteners may promote weight gain by altering circadian rhythms.…”

Section: Discussionmentioning

confidence: 99%

“…This idea is supported by the observation that obesity and insulin resistance are associated with circadian disruption [11]. Recently, saccharin was shown to disrupt circadian sleep-wake cycles and cause physical inactivity in mice [12]. Since obesity and insulin resistance are associated with circadian disruption [11], it is feasible that artificial sweeteners may promote weight gain by altering circadian rhythms.…”

Section: Introductionmentioning

confidence: 99%

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Long term rebaudioside A treatment does not alter circadian activity rhythms, adiposity, or insulin action in male mice

et al. 2017

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Obesity is a major public health problem that is highly associated with insulin resistance and type 2 diabetes, two conditions associated with circadian disruption. To date, dieting is one of the only interventions that result in substantial weight loss, but restricting caloric intake is difficult to maintain long-term. The use of artificial sweeteners, particularly in individuals that consume sugar sweetened beverages (energy drinks, soda), can reduce caloric intake and possibly facilitate weight loss. The purpose of the present study was to examine the effects of the artificial sweetener, rebaudioside A (Reb-A), on circadian rhythms, in vivo insulin action, and the susceptibility to diet-induced obesity. Six month old male C57BL/6 mice were assigned to a control or Reb-A (0.1% Reb-A supplemented drinking water) group for six months. Circadian wheel running rhythms, body weight, caloric intake, insulin action, and susceptibility to diet-induced obesity were assessed. Time of peak physical activity under a 12:12 light-dark (LD) cycle, mean activity levels, and circadian period in constant dark were not significantly different in mice that consumed Reb-A supplemented water compared to normal drinking water, indicating that circadian rhythms and biological clock function were unaltered. Although wheel running significantly reduced body weight in both Reb-A and control mice (P = 0.0001), consuming Reb-A supplemented water did not alter the changes in body weight following wheel running (P = 0.916). In vivo insulin action, as assessed by glucose, insulin, and pyruvate tolerance tests, was not different between mice that consumed Reb-A treated water compared to normal drinking water. Finally, Reb-A does not appear to change the susceptibility to diet-induced obesity as both groups of mice gained similar amounts of body weight when placed on a high fat diet. Our results indicate that consuming Reb-A supplemented water does not promote circadian disruption, insulin resistance, or obesity.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long term rebaudioside A treatment does not alter circadian activity rhythms, adiposity, or insulin action in male mice

et al. 2017

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“…To avoid some food-associated confounds, noncaloric reinforcers can be used, such as saccharine; however, these are rarely as motivating as food restriction and may have unforeseen behavioral consequences, such as sleep disturbances (Oishi et al, 2016) or toxicity (Whitehouse et al, 2008). Additionally, these alternatives may activate alternative sensory and reward systems (Yasoshima et al, 2015; Schier and Spector, 2016; Sclafani and Ackroff, 2016) and may still be susceptible to many of the confounds discussed above (Aoyama et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward

McMurray

Conway

Roitman

2017

eNeuro

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Animal models of decision-making rely on an animal’s motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward (BSR) as an alternative reinforcer in rodent models of decision-making and compared it with the effectiveness of sugar pellets. The discriminability of various BSR frequencies was compared to differing numbers of sugar pellets in separate free-choice tasks. We found that BSR was more discriminable and motivated greater task engagement and more consistent preference for the larger reward. We then investigated whether rats prefer BSR of varying frequencies over sugar pellets. We found that animals showed either a clear preference for sugar reward or no preference between reward modalities, depending on the frequency of the BSR alternative and the size of the sugar reward. Overall, these results suggest that BSR is an effective reinforcer in rodent decision-making tasks, removing food-related confounds and resulting in more accurate, consistent, and reliable metrics of choice.

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“…Os efeitos da tartrazina no comportamento de crianças têm sido reportados, principalmente seus efeitos na hiperatividade (FEINGOLD, 1979 (FEINGOLD, 1979). (OISHI et al, 2016(OISHI et al, , 2018. Todavia, ainda não há estudos em humanos que mostrem efeitos da sacarina no sono.…”

Section: Tartrazinaunclassified

Aditivos Alimentares: Aspectos Gerais E Regulamentação

Nunes¹,

Pereira-Freire²,

Medeiros³

et al. 2020

Aspectos Translacionais Da Toxicodinâmica De Aditivos Alimentares

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Moderately high doses of the artificial sweetener saccharin potentially induce sleep disorders in mice

Cited by 13 publications

References 6 publications

Long term rebaudioside A treatment does not alter circadian activity rhythms, adiposity, or insulin action in male mice

Long term rebaudioside A treatment does not alter circadian activity rhythms, adiposity, or insulin action in male mice

Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward

Aditivos Alimentares: Aspectos Gerais E Regulamentação

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