Moderators of cancer‐related distress and worry after a pancreatic cancer genetic counseling and screening intervention

Hart, Stacey L.; Torbit, Lindsey; Crangle, Cassandra J.; Esplen, Mary Jane; Holter, Spring; Semotiuk, Kara; Borgida, Ayelet; Ardiles, Paola; Rothenmund, Heidi; Gallinger, Steve

doi:10.1002/pon.2026

Cited by 28 publications

(38 citation statements)

References 52 publications

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“…To date, there are no prospective studies with more than 12 months of follow‐up assessing the feasibility of PC surveillance from a psychological point of view. Hart et al found that cancer‐related distress and worries did not increase over the course of 1 year. From our cohort, we previously published the results of 69 individuals who completed a one‐time questionnaire, concluding that PC surveillance by EUS and MRI was feasible from a psychological point of view .…”

Section: Discussionmentioning

confidence: 99%

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Repeated participation in pancreatic cancer surveillance by high‐risk individuals imposes low psychological burden

et al. 2015

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Section: Discussionmentioning

confidence: 99%

“…Only three studies have assessed the feasibility of PC surveillance from a psychological point of view , with a maximum follow‐up of only 12 months. All three conclude that participation in surveillance does not lead to increased psychological distress.…”

Section: Introductionmentioning

confidence: 99%

Repeated participation in pancreatic cancer surveillance by high‐risk individuals imposes low psychological burden

et al. 2015

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“…In these two studies, distress, cancer worry, and risk perception were measured up to 3 months 109 and 1 year. 110 Overall, no significant increases in these outcomes were found over time in these studies, though it was reported that 22.9% of men and 19.9% of women scored above the cutoff for clinical distress at baseline. 109 Distress and cancer worry were higher in patients who were younger and had a strong family history of pancreatic cancer, although individuals with higher baseline distress experienced significant reductions in cancer-related intrusive thoughts over time.…”

Section: Hereditary/familial Pancreatic Cancermentioning

confidence: 65%

“…109 Distress and cancer worry were higher in patients who were younger and had a strong family history of pancreatic cancer, although individuals with higher baseline distress experienced significant reductions in cancer-related intrusive thoughts over time. 109,110 …”

Section: Hereditary/familial Pancreatic Cancermentioning

confidence: 99%

Advances in Hereditary Colorectal and Pancreatic Cancers

Underhill

Germansky

Yurgelun

2016

Clinical Therapeutics

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Purpose Innovations in genetic medicine have lead to improvements in the early detection, prevention, and treatment of cancer for patients with inherited risks of gastrointestinal cancer, particularly hereditary colorectal cancer and hereditary pancreatic cancer. Methods This review provides an update on recent data and key advances that have improved the identification, understanding, and management of patients with hereditary colorectal cancer and hereditary pancreatic cancer. Findings This review details recent and emerging data that highlight the developing landscape of genetics in hereditary colorectal and pancreatic cancer risk. A summary is provided of the current state-of-the-art practices for identifying, evaluating, and managing patients with suspected hereditary colorectal cancer and pancreatic cancer risk. The impact of next-generation sequencing technologies in the clinical diagnosis of hereditary gastrointestinal cancer and also in discovery efforts of novel genes linked to familial cancer risk are discussed. Emerging targeted therapies that may play a particularly important role in the treatment of patients with hereditary forms of colorectal cancer and pancreatic cancer are also reviewed. Current approaches for pancreatic cancer screening and the psychosocial impact of such procedures are also detailed. Implications Given the availability of novel diagnostic, risk-reducing, and therapeutic strategies that exist for patients with hereditary risk for colorectal or pancreatic cancer, it is imperative that clinicians be vigilant about evaluating patients for hereditary cancer syndromes. Continuing to advance genetics research in hereditary gastrointestinal cancers will allow for more progress to be made in personalized medicine and prevention.

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“…Additionally, the risk of rising costs without helpful results or benefits due to pancreatic cancer screening programs is possible [100]. Psychoanalytical aspects for participants in screening programs have been studied and show that the distribution of anxiety and depression are similar to those in the normal populations, although a third worry about cancer [101,102]. This leads to the conclusion that screening in high-risk individuals is feasible and justified [101,103].…”

Section: Considerationmentioning

confidence: 99%

Familial Pancreatic Cancer

Benzel

Fendrich

2018

Oncol Res Treat

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Familial pancreatic cancer accounts for 10% of all patients with pancreatic cancer. Because the 5-year survival rate of pancreatic cancer is only 7%, screening programs for high-risk individuals are essential and might be advantageous. Pancreatic ductal adenocarcinoma mostly shows symptoms at an advanced state and treatment is not efficient enough to cure most patients. People with hereditary tumor syndromes or their affected relatives can also be included in such screening programs. Besides the collection of data to investigate the background of the disease, these screening programs aim to diagnose and treat precursor lesions so that more dangerous, invasive lesions are prevented. These precursor lesions can be pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. This review summarizes the latest knowledge of pancreatic screening programs, shows the procedure of pancreatic cancer screening, and gives an overview of current guidelines.

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Moderators of cancer‐related distress and worry after a pancreatic cancer genetic counseling and screening intervention

Abstract: Analysis of the long-term effects of pancreatic cancer screening and genetic testing reveal psychological gains that are maintained at 1-year follow-up. This intervention is particularly effective for younger participants and individuals with greater baseline distress.

Cited by 28 publications

References 52 publications

Repeated participation in pancreatic cancer surveillance by high‐risk individuals imposes low psychological burden

Repeated participation in pancreatic cancer surveillance by high‐risk individuals imposes low psychological burden

Advances in Hereditary Colorectal and Pancreatic Cancers

Familial Pancreatic Cancer

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